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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2011 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 27 Issue 2

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Article

Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior

  • Authors:
    • Daniel Hernández
    • Laia Miquel-Serra
    • Maria José Docampo
    • Anna Marco-Ramell
    • Anna Bassols

  • View Affiliations / Copyright

    Affiliations: Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain
  • Pages: 269-275
    |
    Published online on: December 6, 2010
       https://doi.org/10.3892/ijmm.2010.577
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Abstract

Versican is a hyaluronan-binding, large extracellular matrix chondroitin sulfate proteoglycan whose expression is increased in malignant melanoma. Binding to hyaluronan allows versican to indirectly interact with the hyaluronan cell surface receptor CD44. The aim of this work was to study the effect of silencing the large versican isoforms (V0 and V1) and CD44 in the SK-mel-131 human melanoma cell line. Versican V0/V1 or CD44 silencing caused a decrease in cell proliferation and migration, both in wound healing assays and in Transwell chambers. Versican V0/V1 silencing also caused an increased adhesion to type I collagen, laminin and fibronectin. These results support the proposed role of versican as a proliferative, anti-adhesive and pro-migratory molecule. On the other hand, CD44 silencing caused a decrease in cell adhesion to vitronectin, fibronectin and hyaluronan. CD44 silencing inhibited the binding of a FITC-hyaluronan complex to the cell surface and its internalization into the cytoplasm. Our results indicate that both versican and CD44 play an important role regulating the behavior of malignant melanoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Hernández D, Miquel-Serra L, Docampo MJ, Marco-Ramell A and Bassols A: Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior. Int J Mol Med 27: 269-275, 2011.
APA
Hernández, D., Miquel-Serra, L., Docampo, M.J., Marco-Ramell, A., & Bassols, A. (2011). Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior. International Journal of Molecular Medicine, 27, 269-275. https://doi.org/10.3892/ijmm.2010.577
MLA
Hernández, D., Miquel-Serra, L., Docampo, M. J., Marco-Ramell, A., Bassols, A."Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior". International Journal of Molecular Medicine 27.2 (2011): 269-275.
Chicago
Hernández, D., Miquel-Serra, L., Docampo, M. J., Marco-Ramell, A., Bassols, A."Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior". International Journal of Molecular Medicine 27, no. 2 (2011): 269-275. https://doi.org/10.3892/ijmm.2010.577
Copy and paste a formatted citation
x
Spandidos Publications style
Hernández D, Miquel-Serra L, Docampo MJ, Marco-Ramell A and Bassols A: Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior. Int J Mol Med 27: 269-275, 2011.
APA
Hernández, D., Miquel-Serra, L., Docampo, M.J., Marco-Ramell, A., & Bassols, A. (2011). Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior. International Journal of Molecular Medicine, 27, 269-275. https://doi.org/10.3892/ijmm.2010.577
MLA
Hernández, D., Miquel-Serra, L., Docampo, M. J., Marco-Ramell, A., Bassols, A."Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior". International Journal of Molecular Medicine 27.2 (2011): 269-275.
Chicago
Hernández, D., Miquel-Serra, L., Docampo, M. J., Marco-Ramell, A., Bassols, A."Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior". International Journal of Molecular Medicine 27, no. 2 (2011): 269-275. https://doi.org/10.3892/ijmm.2010.577
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