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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2011 Volume 27 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea

  • Authors:
    • Jerzy Jankun
    • Magdalena Skotnicka
    • Wiesława Łysiak-Szydłowska
    • Abdulrahman Al-Senaidy
    • Ewa Skrzypczak-Jankun

  • View Affiliations / Copyright

    Affiliations: Urology Research Center, Department of Urology, The University of Toledo - Health Science Campus, 3000 Arlington Ave., Toledo, OH 43614, USA
  • Pages: 525-529
    |
    Published online on: February 9, 2011
       https://doi.org/10.3892/ijmm.2011.615
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Abstract

Fruits, vegetables, spices and a variety of teas are suggested for the prevention of many diseases. They encompass active, non-nutritional ingredients called nutraceuticals which are defined as food products that provide health benefits. Many nutraceuticals have been tested to identify inhibitors of plasminogen activator inhibitor (PAI-1). PAI-1 is the major and fast acting physiological inhibitor of fibrinolysis. However, preclinical studies of PAI-1 inhibitors have revealed an additional role of PAI-1 in the pathogenesis of vascular remodeling, renal injury, diabetes, obesity, Alzheimer’s disease and cancer. Thus PAI-1 is a potential therapeutic target in some of these diseases. Our previous study revealed that a black tea extract (containing mostly theaflavins) inhibits PAI-1. In this study we report results for four pure (>98%) theaflavins. Inactivation of PAI-1 was tested by clot formation and by its lysis using thromboelastometry and measurements of human plasma turbidity. Among four tested theaflavins, theaflavin-3'-gallate was the most potent in PAI-1 inhibition trailed by theaflavin-3,3'-digallate, while the other two i.e., theaflavin and theaflavin-3-gallate did not show inhibitory activity.

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Copy and paste a formatted citation
Spandidos Publications style
Jankun J, Skotnicka M, Łysiak-Szydłowska W, Al-Senaidy A and Skrzypczak-Jankun E: Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. Int J Mol Med 27: 525-529, 2011.
APA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., & Skrzypczak-Jankun, E. (2011). Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. International Journal of Molecular Medicine, 27, 525-529. https://doi.org/10.3892/ijmm.2011.615
MLA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27.4 (2011): 525-529.
Chicago
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27, no. 4 (2011): 525-529. https://doi.org/10.3892/ijmm.2011.615
Copy and paste a formatted citation
x
Spandidos Publications style
Jankun J, Skotnicka M, Łysiak-Szydłowska W, Al-Senaidy A and Skrzypczak-Jankun E: Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. Int J Mol Med 27: 525-529, 2011.
APA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., & Skrzypczak-Jankun, E. (2011). Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. International Journal of Molecular Medicine, 27, 525-529. https://doi.org/10.3892/ijmm.2011.615
MLA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27.4 (2011): 525-529.
Chicago
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27, no. 4 (2011): 525-529. https://doi.org/10.3892/ijmm.2011.615
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