Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea

  • Authors:
    • Jerzy Jankun
    • Magdalena Skotnicka
    • Wiesława Łysiak-Szydłowska
    • Abdulrahman Al-Senaidy
    • Ewa Skrzypczak-Jankun
  • View Affiliations

  • Published online on: February 9, 2011     https://doi.org/10.3892/ijmm.2011.615
  • Pages: 525-529
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Abstract

Fruits, vegetables, spices and a variety of teas are suggested for the prevention of many diseases. They encompass active, non-nutritional ingredients called nutraceuticals which are defined as food products that provide health benefits. Many nutraceuticals have been tested to identify inhibitors of plasminogen activator inhibitor (PAI-1). PAI-1 is the major and fast acting physiological inhibitor of fibrinolysis. However, preclinical studies of PAI-1 inhibitors have revealed an additional role of PAI-1 in the pathogenesis of vascular remodeling, renal injury, diabetes, obesity, Alzheimer’s disease and cancer. Thus PAI-1 is a potential therapeutic target in some of these diseases. Our previous study revealed that a black tea extract (containing mostly theaflavins) inhibits PAI-1. In this study we report results for four pure (>98%) theaflavins. Inactivation of PAI-1 was tested by clot formation and by its lysis using thromboelastometry and measurements of human plasma turbidity. Among four tested theaflavins, theaflavin-3'-gallate was the most potent in PAI-1 inhibition trailed by theaflavin-3,3'-digallate, while the other two i.e., theaflavin and theaflavin-3-gallate did not show inhibitory activity.

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April 2011
Volume 27 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Jankun J, Skotnicka M, Łysiak-Szydłowska W, Al-Senaidy A and Skrzypczak-Jankun E: Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. Int J Mol Med 27: 525-529, 2011
APA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., & Skrzypczak-Jankun, E. (2011). Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea. International Journal of Molecular Medicine, 27, 525-529. https://doi.org/10.3892/ijmm.2011.615
MLA
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27.4 (2011): 525-529.
Chicago
Jankun, J., Skotnicka, M., Łysiak-Szydłowska, W., Al-Senaidy, A., Skrzypczak-Jankun, E."Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea". International Journal of Molecular Medicine 27, no. 4 (2011): 525-529. https://doi.org/10.3892/ijmm.2011.615