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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2011 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2011 Volume 27 Issue 5

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Article

Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications

  • Authors:
    • Daoyun Chen
    • Hao Shen
    • Junjie Shao
    • Yao Jiang
    • Jianxi Lu
    • Yaohua He
    • Chenglong Huang

  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, P.R. China
  • Pages: 707-713
    |
    Published online on: March 2, 2011
       https://doi.org/10.3892/ijmm.2011.634
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Abstract

Bone tissue engineering is a promising cell-based strategy to treat bone defects. Mesenchymal stem cells from adult human bone marrow (hBMSCs) are a frequently used cellular source for bone tissue generation. However, the low frequency of these stem cells in adult bone marrow and their limited proliferation restrict their clinical utility. An alternative source of MSCs is the periosteum-derived cells, and these cells appear to be easy to harvest and expand ex vivo. We isolated human metaphyseal periosteum-derived cells (hMPCs) and hBMSCs from the same donors and compared their osteogenic capacity both in vitro and in vivo. After osteogenic induction in monolayer cultures, hMPCs resulted in more robust mineralization and expressed higher mRNA levels of BMP-2, osteopontin and osteocalcin than hBMSCs. Eight weeks after implantation of cellular-β-TCP scaffolds in immunodeficient mice, hMPC implantation showed higher neovascularization and higher percentage of mature bone formation than hBMSC implantation. In conclusion, hMPCs represent a promising cellular candidate for bone tissue engineering.

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Copy and paste a formatted citation
Spandidos Publications style
Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y and Huang C: Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med 27: 707-713, 2011.
APA
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., & Huang, C. (2011). Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. International Journal of Molecular Medicine, 27, 707-713. https://doi.org/10.3892/ijmm.2011.634
MLA
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., Huang, C."Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications". International Journal of Molecular Medicine 27.5 (2011): 707-713.
Chicago
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., Huang, C."Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications". International Journal of Molecular Medicine 27, no. 5 (2011): 707-713. https://doi.org/10.3892/ijmm.2011.634
Copy and paste a formatted citation
x
Spandidos Publications style
Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y and Huang C: Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med 27: 707-713, 2011.
APA
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., & Huang, C. (2011). Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. International Journal of Molecular Medicine, 27, 707-713. https://doi.org/10.3892/ijmm.2011.634
MLA
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., Huang, C."Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications". International Journal of Molecular Medicine 27.5 (2011): 707-713.
Chicago
Chen, D., Shen, H., Shao, J., Jiang, Y., Lu, J., He, Y., Huang, C."Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications". International Journal of Molecular Medicine 27, no. 5 (2011): 707-713. https://doi.org/10.3892/ijmm.2011.634
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