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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2011 Volume 27 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts

  • Authors:
    • Haruhiko Tokuda
    • Seiji Adachi
    • Rie Matsushima-Nishiwaki
    • Kenji  Kato
    • Hideo Natsume
    • Takanobu Otsuka
    • Osamu Kozawa

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan
  • Pages: 859-864
    |
    Published online on: March 8, 2011
       https://doi.org/10.3892/ijmm.2011.644
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Abstract

It is currently recognized that the Wnt signaling pathway regulates bone mass. We have previously reported that the basic fibroblast growth factor (FGF-2) stimulates the synthesis of the vascular endothelial growth factor (VEGF) at least in part via the p44/p42 mitogen-activated protein (MAP) kinase and the stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the effect of Wnt3a on FGF-2-stimulated VEGF synthesis in MC3T3-E1 cells. Wnt3a significantly augmented the FGF-2-stimulated VEGF release in a dose-dependent manner in the range between 1 and 30 ng/ml. Lithium chloride and SB216763, inhibitors of glycogen synthase kinase 3β (GSK3β), enhanced the FGF-2-stimulated VEGF release. Wnt3a did not affect the phosphorylation of the p44/p42 MAP kinase, SAPK/JNK, Akt, p38 MAP kinase or the p70 S6 kinase induced by FGF-2. Wnt3a and SB216763 increased the levels of VEGF mRNA expression induced by FGF-2. These results strongly suggest that Wnt3a enhances VEGF synthesis stimulated by FGF-2 via activation of the canonical Wnt/β-catenin pathway in osteoblasts.

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Copy and paste a formatted citation
Spandidos Publications style
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Natsume H, Otsuka T and Kozawa O: Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts. Int J Mol Med 27: 859-864, 2011.
APA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., & Kozawa, O. (2011). Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts. International Journal of Molecular Medicine, 27, 859-864. https://doi.org/10.3892/ijmm.2011.644
MLA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., Kozawa, O."Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts". International Journal of Molecular Medicine 27.6 (2011): 859-864.
Chicago
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., Kozawa, O."Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts". International Journal of Molecular Medicine 27, no. 6 (2011): 859-864. https://doi.org/10.3892/ijmm.2011.644
Copy and paste a formatted citation
x
Spandidos Publications style
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Natsume H, Otsuka T and Kozawa O: Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts. Int J Mol Med 27: 859-864, 2011.
APA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., & Kozawa, O. (2011). Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts. International Journal of Molecular Medicine, 27, 859-864. https://doi.org/10.3892/ijmm.2011.644
MLA
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., Kozawa, O."Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts". International Journal of Molecular Medicine 27.6 (2011): 859-864.
Chicago
Tokuda, H., Adachi, S., Matsushima-Nishiwaki, R., Kato, K., Natsume, H., Otsuka, T., Kozawa, O."Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts". International Journal of Molecular Medicine 27, no. 6 (2011): 859-864. https://doi.org/10.3892/ijmm.2011.644
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