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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2011 Volume 28 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells

  • Authors:
    • Martina Haselberger
    • Anette Springwald
    • Anna Konwisorz
    • Claus Lattrich
    • Regina Goerse
    • Olaf Ortmann
    • Oliver Treeck

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany, Department of Obstetrics and Gynecology, University of Regensburg, Caritas Krankenhaus St. Josef, Landshuter Strasse 65, D-93053 Regensburg, Germany
  • Pages: 121-127
    |
    Published online on: March 31, 2011
       https://doi.org/10.3892/ijmm.2011.663
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Abstract

Icb-1 (C1orf38) is a human gene initially described by our group to be involved in differentiation processes of cancer cells. To further elucidate the function of the icb-1 gene in differentiation of breast and endometrial cancer cells, we knocked down its expression by means of shRNA transfection. Knockdown of icb-1 inhibited the vitamin D3-induced up-regulation of E-cadherin expression in both MCF-7 and HEC-1B cells. Induction of E-cadherin expression by all-trans retinoic acid (ATRA) was also blocked in both cell lines expressing icb-1 siRNA. Examination of icb-1 and E-cadherin expression in 66 breast cancer tissue samples revealed a significant positive correlation between the two genes. In MCF-7 cells, silencing of the icb-1 gene inhibited the ATRA- and the vitamin D3-induced up-regulation of lactoferrin and estrogen receptor β expression. The data of our knockdown study suggest that icb-1 may act as a mediator of differentiation signals in breast cancer cells induced by ATRA or vitamin D3. These findings together with the observed co-expression of icb-1 with E-cadherin in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Haselberger M, Springwald A, Konwisorz A, Lattrich C, Goerse R, Ortmann O and Treeck O: Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells. Int J Mol Med 28: 121-127, 2011.
APA
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., & Treeck, O. (2011). Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells. International Journal of Molecular Medicine, 28, 121-127. https://doi.org/10.3892/ijmm.2011.663
MLA
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., Treeck, O."Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine 28.1 (2011): 121-127.
Chicago
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., Treeck, O."Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine 28, no. 1 (2011): 121-127. https://doi.org/10.3892/ijmm.2011.663
Copy and paste a formatted citation
x
Spandidos Publications style
Haselberger M, Springwald A, Konwisorz A, Lattrich C, Goerse R, Ortmann O and Treeck O: Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells. Int J Mol Med 28: 121-127, 2011.
APA
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., & Treeck, O. (2011). Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells. International Journal of Molecular Medicine, 28, 121-127. https://doi.org/10.3892/ijmm.2011.663
MLA
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., Treeck, O."Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine 28.1 (2011): 121-127.
Chicago
Haselberger, M., Springwald, A., Konwisorz, A., Lattrich, C., Goerse, R., Ortmann, O., Treeck, O."Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine 28, no. 1 (2011): 121-127. https://doi.org/10.3892/ijmm.2011.663
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