Effects of electrolytes on virus inactivation by acidic solutions

  • Authors:
    • Mitsunori Nishide
    • Kazuko Tsujimoto
    • Misao Uozaki
    • Keiko Ikeda
    • Hisashi Yamasaki
    • A. Hajime Koyama
    • Tsutomu Arakawa
  • View Affiliations

  • Published online on: April 4, 2011     https://doi.org/10.3892/ijmm.2011.668
  • Pages: 803-809
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Abstract

Acidic pH is frequently used to inactivate viruses. We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of superficial virus infection at body surfaces and fixtures, herein we have examined the effects of various electrolytes on the acid-induced inactivation of the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), the influenza A virus (IAV) and the poliovirus upon their incubation at 30˚C for 5 min. Eight electrolytes, i.e., phosphate, NaCl, glutamate, aspartate, pyrrolidone carboxylate, citrate, malate and acetate were tested. No detectable inactivation of the poliovirus was observed under the conditions examined, reflecting its acid-resistance. HSV-1 and HSV-2 responded similarly to the acid-treatment and electrolytes. Some electrolytes showed a stronger virus inactivation than others at a given pH and concentration. The effects of the electrolytes were virus-dependent, as IAV responded differently from HSV-1 and HSV-2 to these electrolytes, indicating that certain combinations of the electrolytes and a low pH can exert a more effective virus inactivation than other combinations and that their effects are virus-specific. These results should be useful in designing acidic solvents for the inactivation of viruses at various surfaces.

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June 2011
Volume 27 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nishide M, Tsujimoto K, Uozaki M, Ikeda K, Yamasaki H, Koyama AH and Arakawa T: Effects of electrolytes on virus inactivation by acidic solutions. Int J Mol Med 27: 803-809, 2011
APA
Nishide, M., Tsujimoto, K., Uozaki, M., Ikeda, K., Yamasaki, H., Koyama, A.H., & Arakawa, T. (2011). Effects of electrolytes on virus inactivation by acidic solutions. International Journal of Molecular Medicine, 27, 803-809. https://doi.org/10.3892/ijmm.2011.668
MLA
Nishide, M., Tsujimoto, K., Uozaki, M., Ikeda, K., Yamasaki, H., Koyama, A. H., Arakawa, T."Effects of electrolytes on virus inactivation by acidic solutions". International Journal of Molecular Medicine 27.6 (2011): 803-809.
Chicago
Nishide, M., Tsujimoto, K., Uozaki, M., Ikeda, K., Yamasaki, H., Koyama, A. H., Arakawa, T."Effects of electrolytes on virus inactivation by acidic solutions". International Journal of Molecular Medicine 27, no. 6 (2011): 803-809. https://doi.org/10.3892/ijmm.2011.668