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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2011 Volume 28 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2011 Volume 28 Issue 3

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Article

Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers

  • Authors:
    • Α. Μ. Nurul-Syakima
    • C. Yoke-Kqueen
    • A. R. Sabariah
    • M. S. Shiran
    • A. Singh
    • L. Learn-Han

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia, Department of Biomedical Science, Faculty of Medicine and Health Sciences, and UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia
  • Pages: 327-336
    |
    Published online on: June 1, 2011
       https://doi.org/10.3892/ijmm.2011.714
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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that involved in various cancer-related cellular processes. Diverse studies on expression profiling of miRNAs have been performed and the data showed that some miRNAs are up-regulated or down-regulated in cancer. Until now, there are no data published on the miRNA expression in head and neck cancers from Malaysia. Hence, this study aimed to investigate potentially crucial miRNAs in head and neck cancer patients from Malaysian populations. A global miRNA profiling was performed on 12 samples of head and neck cancer tissue using microarray analysis followed by validation using real-time RT-PCR. Microarray analysis identified 10 miRNAs that could distinguish malignant head and neck cancer lesions from normal tissues; 7 miRNAs (hsa-miR-181a-2*, hsa-miR-29b-1*, hsa-miR-181a, hsa-miR-181b, hsa-miR-744, hsa-miR-1271 and hsa-miR-221*) were up-regulated while 3 miRNAs (hsa-miR-141, hsa-miR-95 and hsa-miR-101) were down-regulated. These miRNAs may contribute in a simple profiling strategy to identify individuals at higher risk of developing head and neck cancers, thus helping in the elucidation of the molecular mechanisms involved in head and neck cancer pathogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Nurul-Syakima ΑΜ, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A and Learn-Han L: Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med 28: 327-336, 2011.
APA
Nurul-Syakima, Α.Μ., Yoke-Kqueen, C., Sabariah, A.R., Shiran, M.S., Singh, A., & Learn-Han, L. (2011). Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. International Journal of Molecular Medicine, 28, 327-336. https://doi.org/10.3892/ijmm.2011.714
MLA
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28.3 (2011): 327-336.
Chicago
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28, no. 3 (2011): 327-336. https://doi.org/10.3892/ijmm.2011.714
Copy and paste a formatted citation
x
Spandidos Publications style
Nurul-Syakima ΑΜ, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A and Learn-Han L: Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med 28: 327-336, 2011.
APA
Nurul-Syakima, Α.Μ., Yoke-Kqueen, C., Sabariah, A.R., Shiran, M.S., Singh, A., & Learn-Han, L. (2011). Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. International Journal of Molecular Medicine, 28, 327-336. https://doi.org/10.3892/ijmm.2011.714
MLA
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28.3 (2011): 327-336.
Chicago
Nurul-Syakima, Α. Μ., Yoke-Kqueen, C., Sabariah, A. R., Shiran, M. S., Singh, A., Learn-Han, L."Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine 28, no. 3 (2011): 327-336. https://doi.org/10.3892/ijmm.2011.714
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