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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2011 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 28 Issue 4

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Article

miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells

  • Authors:
    • Xin Huang
    • Shujun Xu
    • Jie Gao
    • Fei Liu
    • Jing Yue
    • Ting Chen
    • Buling Wu

  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Nanfang Hospital, Southern Medical University, College of Stomatology, Southern Medical University, Guangzhou, P.R. China, Department of Stomatology, Nanfang Hospital, Southern Medical University, College of Stoma­tology, Southern Medical University, Guangzhou, P.R. China
  • Pages: 659-667
    |
    Published online on: June 15, 2011
       https://doi.org/10.3892/ijmm.2011.721
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Abstract

Dentin sialophosphoprotein (DSPP), an important marker of odontoblast differentiation, is a prerequisite for tooth development and mineralization; however, the molecular mechanisms of both temporal and spatial regulation remain unknown. MicroRNAs (miRNAs) provide an additional level of control beyond that of transcription factors, which regulate post-transcriptional control of gene expression. The present study was designed to provide a first attempt at an in-depth analysis of dental pulp cells at various odontoblastic differentiation stages to obtain miRNA differential expression patterns, and to determine the contribution of miRNAs in the expression of DSPP during odontoblast differentiation. Dual luciferase reporter assays and qRT-PCR were used to validate miRNAs identified from bioinformatic analyses to determine whether they were able to regulate the DSPP gene in dental pulp cells cultured in a mineralizing medium. The results presented here suggest that DSPP is regulated post-transcriptionally by mir32, mir885-5p and mir586 during odontoblast differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Huang X, Xu S, Gao J, Liu F, Yue J, Chen T and Wu B: miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. Int J Mol Med 28: 659-667, 2011.
APA
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., & Wu, B. (2011). miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. International Journal of Molecular Medicine, 28, 659-667. https://doi.org/10.3892/ijmm.2011.721
MLA
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., Wu, B."miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". International Journal of Molecular Medicine 28.4 (2011): 659-667.
Chicago
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., Wu, B."miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". International Journal of Molecular Medicine 28, no. 4 (2011): 659-667. https://doi.org/10.3892/ijmm.2011.721
Copy and paste a formatted citation
x
Spandidos Publications style
Huang X, Xu S, Gao J, Liu F, Yue J, Chen T and Wu B: miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. Int J Mol Med 28: 659-667, 2011.
APA
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., & Wu, B. (2011). miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells. International Journal of Molecular Medicine, 28, 659-667. https://doi.org/10.3892/ijmm.2011.721
MLA
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., Wu, B."miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". International Journal of Molecular Medicine 28.4 (2011): 659-667.
Chicago
Huang, X., Xu, S., Gao, J., Liu, F., Yue, J., Chen, T., Wu, B."miRNA expression profiling identifies DSPP regulators in cultured dental pulp cells". International Journal of Molecular Medicine 28, no. 4 (2011): 659-667. https://doi.org/10.3892/ijmm.2011.721
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