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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2011 Volume 28 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines

  • Authors:
    • Martin Laschak
    • Marina Bechtel
    • Klaus-Dieter Spindler
    • Andrea Hessenauer
  • View Affiliations / Copyright

    Affiliations: Institute of General Zoology and Endocrinology, Ulm University, Albert-Einstein-Allee 11, D-89069 Ulm, Germany
  • Pages: 645-651
    |
    Published online on: June 27, 2011
       https://doi.org/10.3892/ijmm.2011.735
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Abstract

The molecular mechanisms leading to castration-resistant prostate cancer (CRPC) are poorly understood. Among several mechanisms leading to CRPC growth a dysregulation of androgen receptor (AR) co-regulators (i.e. up-regulation of co-activators or down-regulation of co-repressors) is discussed. There are numerous reports demonstrating an increased expression of co-activators during prostate cancer progression. On the contrary, the impact of co-repressors on tumor growth and development is less clear. In this study we compared the effects of two known co-repressors, NCoR and SMRT, on AR transcriptional activity in prostate cancer (PCa) cell lines and compared them to that in COS-1 cells. Interestingly, we found that NCoR/SMRT overexpression did not repress AR-dependent gene expression in the PCa cell lines, but rather activated it. This finding is probably due to an impaired AR-co-repressor interaction in the prostate cancer cell lines. In conclusion, we provide evidence that up-regulation of NCoR or SMRT may increase transcriptional activity of the AR in a cell type-specific context.

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Copy and paste a formatted citation
Spandidos Publications style
Laschak M, Bechtel M, Spindler K and Hessenauer A: Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. Int J Mol Med 28: 645-651, 2011.
APA
Laschak, M., Bechtel, M., Spindler, K., & Hessenauer, A. (2011). Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. International Journal of Molecular Medicine, 28, 645-651. https://doi.org/10.3892/ijmm.2011.735
MLA
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28.4 (2011): 645-651.
Chicago
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28, no. 4 (2011): 645-651. https://doi.org/10.3892/ijmm.2011.735
Copy and paste a formatted citation
x
Spandidos Publications style
Laschak M, Bechtel M, Spindler K and Hessenauer A: Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. Int J Mol Med 28: 645-651, 2011.
APA
Laschak, M., Bechtel, M., Spindler, K., & Hessenauer, A. (2011). Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines. International Journal of Molecular Medicine, 28, 645-651. https://doi.org/10.3892/ijmm.2011.735
MLA
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28.4 (2011): 645-651.
Chicago
Laschak, M., Bechtel, M., Spindler, K., Hessenauer, A."Inability of NCoR/SMRT to repress androgen receptor transcriptional activity in prostate cancer cell lines". International Journal of Molecular Medicine 28, no. 4 (2011): 645-651. https://doi.org/10.3892/ijmm.2011.735
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