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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2011 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 28 Issue 4

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Article

Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers

  • Authors:
    • David Adler
    • Andreas Lindstrot
    • Reinhard Buettner
    • Nicolas Wernert
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, University Hospital Bonn, D-53127 Bonn, Germany, Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany
  • Pages: 605-611
    |
    Published online on: July 8, 2011
       https://doi.org/10.3892/ijmm.2011.746
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Abstract

Prostate cancer (PCA) is a clinically heterogeneous and often multifocal disease with a clinical outcome difficult to predict. A deeper knowledge of the molecular basis of the disease may lead to a better prediction of prognosis. Therefore, in this study we investigated the molecular basis of PCA by identifying potential tumor markers in laser-microdisected PCA tissues. Among a group of PCA patients, quantitative RT-PCR analysis was performed to compare the expression of 70 genes. These genes were selected from the results of two microarrays which investigated the gene expression profile differences between moderately or poorly differentiated prostate carcinoma glands and the corresponding normal glands. Among the genes examined, CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands, whereas TFF3, TMPRSS2 and ERG were up-regulated. Our findings indicate that these genes may play roles as tumor suppressor genes or oncogenes in PCA, and may serve as potential tumor markers and novel therapeutic targets.

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Copy and paste a formatted citation
Spandidos Publications style
Adler D, Lindstrot A, Buettner R and Wernert N: Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. Int J Mol Med 28: 605-611, 2011.
APA
Adler, D., Lindstrot, A., Buettner, R., & Wernert, N. (2011). Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. International Journal of Molecular Medicine, 28, 605-611. https://doi.org/10.3892/ijmm.2011.746
MLA
Adler, D., Lindstrot, A., Buettner, R., Wernert, N."Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers". International Journal of Molecular Medicine 28.4 (2011): 605-611.
Chicago
Adler, D., Lindstrot, A., Buettner, R., Wernert, N."Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers". International Journal of Molecular Medicine 28, no. 4 (2011): 605-611. https://doi.org/10.3892/ijmm.2011.746
Copy and paste a formatted citation
x
Spandidos Publications style
Adler D, Lindstrot A, Buettner R and Wernert N: Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. Int J Mol Med 28: 605-611, 2011.
APA
Adler, D., Lindstrot, A., Buettner, R., & Wernert, N. (2011). Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. International Journal of Molecular Medicine, 28, 605-611. https://doi.org/10.3892/ijmm.2011.746
MLA
Adler, D., Lindstrot, A., Buettner, R., Wernert, N."Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers". International Journal of Molecular Medicine 28.4 (2011): 605-611.
Chicago
Adler, D., Lindstrot, A., Buettner, R., Wernert, N."Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers". International Journal of Molecular Medicine 28, no. 4 (2011): 605-611. https://doi.org/10.3892/ijmm.2011.746
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