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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2011 Volume 28 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 28 Issue 5

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Article

Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts

  • Authors:
    • Kenji Kato
    • Haruhiko Tokuda
    • Jun Mizutani
    • Seiji Adachi
    • Rie Matsushima-Nishiwaki
    • Hideo Natsume
    • Osamu Kozawa
    • Takanobu Otsuka

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8602, Japan, Department of Pharma­cology, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu 501-1194, Japan
  • Pages: 887-893
    |
    Published online on: August 2, 2011
       https://doi.org/10.3892/ijmm.2011.762
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Abstract

Heat shock protein 27 (HSP27) is known to act as a molecular chaperone. We have recently reported that HSP27 regulates osteocalcin synthesis in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the role of HSP27 in tumor necrosis factor-α (TNF-α)-stimulated interleukin-6 (IL-6) synthesis in MC3T3-E1 cells. The levels of IL-6 release and IL-6 mRNA stimulated by TNF-α in MC3T3-E1 cells transfected with HSP27 was significantly higher than those in the control cells. In addition, the levels of secreted IL-6 and IL-6 mRNA in the phospho-mimic HSP27-overexpressing cells were significantly higher than those in the non-phosphoryl­atable HSP27-overexpressing cells. Furthermore, we observed no significant differences in the phosphorylation levels of IκB/NFκB, Akt, and p44/p42 mitogen-activated protein kinase among the 4 types of transfected cells. Therefore, these results strongly suggest that HSP27 enhances TNF-α-stimulated IL-6 synthesis, and that the phosphorylation status of HSP27 is related to IL-6 synthesis in osteoblasts.

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Copy and paste a formatted citation
Spandidos Publications style
Kato K, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Otsuka T: Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts. Int J Mol Med 28: 887-893, 2011.
APA
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H. ... Otsuka, T. (2011). Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts. International Journal of Molecular Medicine, 28, 887-893. https://doi.org/10.3892/ijmm.2011.762
MLA
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Otsuka, T."Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts". International Journal of Molecular Medicine 28.5 (2011): 887-893.
Chicago
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Otsuka, T."Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts". International Journal of Molecular Medicine 28, no. 5 (2011): 887-893. https://doi.org/10.3892/ijmm.2011.762
Copy and paste a formatted citation
x
Spandidos Publications style
Kato K, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Otsuka T: Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts. Int J Mol Med 28: 887-893, 2011.
APA
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H. ... Otsuka, T. (2011). Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts. International Journal of Molecular Medicine, 28, 887-893. https://doi.org/10.3892/ijmm.2011.762
MLA
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Otsuka, T."Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts". International Journal of Molecular Medicine 28.5 (2011): 887-893.
Chicago
Kato, K., Tokuda, H., Mizutani, J., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Otsuka, T."Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts". International Journal of Molecular Medicine 28, no. 5 (2011): 887-893. https://doi.org/10.3892/ijmm.2011.762
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