Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm

  • Authors:
    • Kimihiko Kato
    • Yoshiyuki Tokuda
    • Naohiko Inagaki
    • Tetsuro Yoshida
    • Tetsuo Fujimaki
    • Mitsutoshi Oguri
    • Takeshi Hibino
    • Kiyoshi Yokoi
    • Toyoaki Murohara
    • Yoshiji Yamada
  • View Affiliations

  • Published online on: September 30, 2011     https://doi.org/10.3892/ijmm.2011.804
  • Pages: 125-132
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Abstract

Although genetic variants are thought to contribute to the development of thoracic aortic aneurysm including dissection (TAA), it remains unclear whether gene polymorphisms are associated with the long-term outcome of TAA. The purpose of the present study was to identify genetic variants associated with the long-term outcome of medically treated patients with TAA. A total of 103 medically-treated patients with TAA (13 aneurysms and 90 dissections) were retrospectively studied for their outcomes (mean follow-up period, 24 months). The genotypes for 95 polymorphisms of 89 candidate genes were determined by a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Evaluation of genotype distributions by the Chi-square test and subsequent multivariable logistic regression analysis with adjustment for covariates revealed that the -340A→G polymorphism (rs514921) of the matrix metallopeptidase 1 gene (MMP1) was significantly (P=0.0288) associated with the outcome of TAA, with the minor G allele being related to a favorable outcome. The aneurysm diameter was significantly (P=0.0167) smaller in the combined group of the AG and GG genotypes for this polymorphism than in subjects with the AA genotype. Kaplan-Meier survival curves constructed according to MMP1 genotypes showed a more favorable outcome of TAA (log-rank P=0.0146) in subjects with the G allele of rs514921. Determination of genotype for this polymorphism may prove informative for assessment of the long-term outcome of TAA.

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January 2012
Volume 29 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kato K, Tokuda Y, Inagaki N, Yoshida T, Fujimaki T, Oguri M, Hibino T, Yokoi K, Murohara T, Yamada Y, Yamada Y, et al: Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm. Int J Mol Med 29: 125-132, 2012
APA
Kato, K., Tokuda, Y., Inagaki, N., Yoshida, T., Fujimaki, T., Oguri, M. ... Yamada, Y. (2012). Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm. International Journal of Molecular Medicine, 29, 125-132. https://doi.org/10.3892/ijmm.2011.804
MLA
Kato, K., Tokuda, Y., Inagaki, N., Yoshida, T., Fujimaki, T., Oguri, M., Hibino, T., Yokoi, K., Murohara, T., Yamada, Y."Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm". International Journal of Molecular Medicine 29.1 (2012): 125-132.
Chicago
Kato, K., Tokuda, Y., Inagaki, N., Yoshida, T., Fujimaki, T., Oguri, M., Hibino, T., Yokoi, K., Murohara, T., Yamada, Y."Association of a matrix metallopeptidase 1 gene polymorphism with long-term outcome of thoracic aortic aneurysm". International Journal of Molecular Medicine 29, no. 1 (2012): 125-132. https://doi.org/10.3892/ijmm.2011.804