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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2012 Volume 29 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2012 Volume 29 Issue 3

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Article

TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis

Retraction in: /10.3892/ijmm.2023.5251
  • Authors:
    • Zhi-Dong Lv
    • Hai-Bo Wang
    • Fu-Nian Li
    • Li Wu
    • Chen Liu
    • Gang Nie
    • Bin Kong
    • Hui-Li Qu
    • Jian-Guo Li

  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, P.R. China, Department of Breast Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, P.R. China
  • Pages: 373-379
    |
    Published online on: December 1, 2011
       https://doi.org/10.3892/ijmm.2011.852
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Abstract

Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Our previous study demonstrated that peritoneal fibrosis induced by transforming growth factor-β1 (TGF-β1) may provide a favorable environment for the dissemination of gastric cancer. The role of Smad3 in the development of dermal fibrosis, subcapsular cataract, and peritoneal fibrosis has been reported. However, the potential role of Smad2 in the development of fibrosis is unclear. The objective of this study was to determine the effect of Smad2 in peritoneal fibrosis, induced by TGF-β1, on dissemination of gastric cancer. Here we demonstrate that TGF-β1 significantly stimulated the expression of collagen III and fibronectin in mesothelial cells through the Smad2 signal transduction pathway, but knockdown of the Smad2 gene by silencing siRNA partially inhibited these effects. This inhibition was associated with a depressed adhesion and invasiveness of gastric cancer cells. We conclude that peritoneal fibrosis induced by TGF-β1 is dependent on Smad2 signaling and may provide a hospitable environment for carcinomatosis.

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Copy and paste a formatted citation
Spandidos Publications style
Lv Z, Wang H, Li F, Wu L, Liu C, Nie G, Kong B, Qu H and Li J: TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251. Int J Mol Med 29: 373-379, 2012.
APA
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G. ... Li, J. (2012). TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251. International Journal of Molecular Medicine, 29, 373-379. https://doi.org/10.3892/ijmm.2011.852
MLA
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G., Kong, B., Qu, H., Li, J."TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251". International Journal of Molecular Medicine 29.3 (2012): 373-379.
Chicago
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G., Kong, B., Qu, H., Li, J."TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251". International Journal of Molecular Medicine 29, no. 3 (2012): 373-379. https://doi.org/10.3892/ijmm.2011.852
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Z, Wang H, Li F, Wu L, Liu C, Nie G, Kong B, Qu H and Li J: TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251. Int J Mol Med 29: 373-379, 2012.
APA
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G. ... Li, J. (2012). TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251. International Journal of Molecular Medicine, 29, 373-379. https://doi.org/10.3892/ijmm.2011.852
MLA
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G., Kong, B., Qu, H., Li, J."TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251". International Journal of Molecular Medicine 29.3 (2012): 373-379.
Chicago
Lv, Z., Wang, H., Li, F., Wu, L., Liu, C., Nie, G., Kong, B., Qu, H., Li, J."TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis Retraction in /10.3892/ijmm.2023.5251". International Journal of Molecular Medicine 29, no. 3 (2012): 373-379. https://doi.org/10.3892/ijmm.2011.852
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