A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

  • Authors:
    • Tadaomi Kawashima
    • Katsura Murakami
    • Ikuko Nishimura
    • Takahisa Nakano
    • Akio Obata
  • View Affiliations

  • Published online on: December 5, 2011     https://doi.org/10.3892/ijmm.2011.854
  • Pages: 447-453
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Abstract

Fucoidan, a sulfated polysaccharide contained in brown algae, has a variety of immunomodulatory effects, including antitumor and antiviral effects. On the other hand, lactic acid bacteria (LAB) also have immunomodulatory effects such as anti-allergic effects. In this study, we demonstrated that fucoidan enhances the probiotic effects of LAB on immune functions. By using Peyer's patch cells and spleen cells in vitro, fucoidan amplified interferon (IFN)-γ production in response to a strain of LAB, Tetragenococcus halophilus KK221, and this activity was abolished by desulfation of fucoidan. Moreover, this IFN-γ response was abolished by interleukin (IL)-12 neutralization. These results indicate that fucoidan enhanced IL-12 production in response to KK221, resulting in promoting IFN-γ production. In an in vivo study, Th1/Th2 immunobalance was most improved by oral administration of both fucoidan and KK221 to ovalbumin-immunized mice. These findings suggest that fucoidan can enhance a variety of beneficial effects of LAB on immune functions.

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March 2012
Volume 29 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kawashima T, Murakami K, Nishimura I, Nakano T and Obata A: A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria. Int J Mol Med 29: 447-453, 2012
APA
Kawashima, T., Murakami, K., Nishimura, I., Nakano, T., & Obata, A. (2012). A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria. International Journal of Molecular Medicine, 29, 447-453. https://doi.org/10.3892/ijmm.2011.854
MLA
Kawashima, T., Murakami, K., Nishimura, I., Nakano, T., Obata, A."A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria". International Journal of Molecular Medicine 29.3 (2012): 447-453.
Chicago
Kawashima, T., Murakami, K., Nishimura, I., Nakano, T., Obata, A."A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria". International Journal of Molecular Medicine 29, no. 3 (2012): 447-453. https://doi.org/10.3892/ijmm.2011.854