Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells

  • Authors:
    • Yoonkyung Woo
    • Soon Young Shin
    • Jiye Hyun
    • Sung Dae Lee
    • Young Han Lee
    • Yoongho Lim
  • View Affiliations

  • Published online on: December 12, 2011     https://doi.org/10.3892/ijmm.2011.857
  • Pages: 403-408
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Abstract

Naringenin has been shown to display various biological effects such as antioxidant, anticancer, anti-inflammatory, and antiviral activities. Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. They all belong to flavanone which is a class of flavonoids with a C6-C3-C6 skeleton. Since the anticancer activities of flavanone derivatives have rarely been reported, we examined the effects of 26 flavanone derivatives on HCT116 colorectal cancer cells. Our results suggest that flavanone derivatives control the expression of cell cycle regulatory proteins, which blocks G1 cell cycle progression and inhibits the clonogenicity of HCT116 cells. In addition, in order to design flavanone derivatives that show better anticancer activity, structure-activity relationships were examined.

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March 2012
Volume 29 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Woo Y, Shin SY, Hyun J, Lee SD, Lee YH and Lim Y: Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells. Int J Mol Med 29: 403-408, 2012.
APA
Woo, Y., Shin, S.Y., Hyun, J., Lee, S.D., Lee, Y.H., & Lim, Y. (2012). Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells. International Journal of Molecular Medicine, 29, 403-408. https://doi.org/10.3892/ijmm.2011.857
MLA
Woo, Y., Shin, S. Y., Hyun, J., Lee, S. D., Lee, Y. H., Lim, Y."Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells". International Journal of Molecular Medicine 29.3 (2012): 403-408.
Chicago
Woo, Y., Shin, S. Y., Hyun, J., Lee, S. D., Lee, Y. H., Lim, Y."Flavanones inhibit the clonogenicity of HCT116 cololectal cancer cells". International Journal of Molecular Medicine 29, no. 3 (2012): 403-408. https://doi.org/10.3892/ijmm.2011.857