Open Access

Role of lactate and lactate metabolism in liver diseases (Review)

  • Authors:
    • Shun Yao
    • Hongyu Chai
    • Ting Tao
    • Li Zhang
    • Xingyue Yang
    • Xin Li
    • Zhiqiang Yi
    • Yongfeng Wang
    • Jiaxin An
    • Guorong Wen
    • Hai Jin
    • Biguang Tuo
  • View Affiliations

  • Published online on: May 20, 2024     https://doi.org/10.3892/ijmm.2024.5383
  • Article Number: 59
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which glucose can be fermented in the presence of oxygen to produce lactate) it was considered a metabolic waste product. At present, lactate is not only recognized as a metabolic substrate that provides energy, but also as a signaling molecule that regulates cellular functions under pathophysiological conditions. Lactylation, a post‑translational modification, is involved in the development of various diseases, including inflammation and tumors. Liver disease is a major health challenge worldwide. In normal liver, there is a net lactate uptake caused by gluconeogenesis, exhibiting a higher net lactate clearance rate compared with any other organ. Therefore, abnormalities of lactate and lactate metabolism lead to the development of liver disease, and lactate and lactate metabolism‑related genes can be used for predicting the prognosis of liver disease. Targeting lactate production, regulating lactate transport and modulating lactylation may be potential treatment approaches for liver disease. However, currently there is not a systematic review that summarizes the role of lactate and lactate metabolism in liver diseases. In the present review, the role of lactate and lactate metabolism in liver diseases including liver fibrosis, non‑alcoholic fatty liver disease, acute liver failure and hepatocellular carcinoma was summarized with the aim to provide insights for future research.

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July-2024
Volume 54 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Yao S, Chai H, Tao T, Zhang L, Yang X, Li X, Yi Z, Wang Y, An J, Wen G, Wen G, et al: Role of lactate and lactate metabolism in liver diseases (Review). Int J Mol Med 54: 59, 2024
APA
Yao, S., Chai, H., Tao, T., Zhang, L., Yang, X., Li, X. ... Tuo, B. (2024). Role of lactate and lactate metabolism in liver diseases (Review). International Journal of Molecular Medicine, 54, 59. https://doi.org/10.3892/ijmm.2024.5383
MLA
Yao, S., Chai, H., Tao, T., Zhang, L., Yang, X., Li, X., Yi, Z., Wang, Y., An, J., Wen, G., Jin, H., Tuo, B."Role of lactate and lactate metabolism in liver diseases (Review)". International Journal of Molecular Medicine 54.1 (2024): 59.
Chicago
Yao, S., Chai, H., Tao, T., Zhang, L., Yang, X., Li, X., Yi, Z., Wang, Y., An, J., Wen, G., Jin, H., Tuo, B."Role of lactate and lactate metabolism in liver diseases (Review)". International Journal of Molecular Medicine 54, no. 1 (2024): 59. https://doi.org/10.3892/ijmm.2024.5383