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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April-2026 Volume 57 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

  • Authors:
    • Yongchun Liang
    • Xinbiao Fan
    • Xiaofei Geng
    • Yunfeng Jia
    • Wenyu Shang
    • Xitong Sun
    • Jun Ge
    • Guijun Ye
    • Boyu Zhu
    • Zheng Zhang
    • Yuxin Kang
    • Xiaoyu Shan
    • Junping Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, P.R. China, Department of Cardiology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330200, P.R. China, College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 82
    |
    Published online on: February 3, 2026
       https://doi.org/10.3892/ijmm.2026.5753
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Abstract

Diabetic cardiomyopathy (DCM) is a significant complication in patients with diabetes, but its pathogenesis is not fully understood. In recent years, dynamic regulation of lipid droplets (LDs) balance has gradually become a new therapeutic direction with great potential. LDs regulate lipid storage, energy supply and interconnected drivers; for instance, oxidative damage, inflammation, autophagy, ferroptosis, affect the function and cellular homeostasis of cardiomyocytes, macrophages and fibroblasts, and thus participate in DCM. The present review discusses the multiple functions of LDs in regulating DCM by affecting cell homeostasis and summarizes the research progress of therapies targeting LDs and related metabolic pathways, which may inform novel strategies for preventing and treating DCM.

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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Fan X, Geng X, Jia Y, Shang W, Sun X, Ge J, Ye G, Zhu B, Zhang Z, Zhang Z, et al: <p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>. Int J Mol Med 57: 82, 2026.
APA
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X. ... Zhang, J. (2026). <p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>. International Journal of Molecular Medicine, 57, 82. https://doi.org/10.3892/ijmm.2026.5753
MLA
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X., Ge, J., Ye, G., Zhu, B., Zhang, Z., Kang, Y., Shan, X., Zhang, J."<p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 82.
Chicago
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X., Ge, J., Ye, G., Zhu, B., Zhang, Z., Kang, Y., Shan, X., Zhang, J."<p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 82. https://doi.org/10.3892/ijmm.2026.5753
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Fan X, Geng X, Jia Y, Shang W, Sun X, Ge J, Ye G, Zhu B, Zhang Z, Zhang Z, et al: <p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>. Int J Mol Med 57: 82, 2026.
APA
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X. ... Zhang, J. (2026). <p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>. International Journal of Molecular Medicine, 57, 82. https://doi.org/10.3892/ijmm.2026.5753
MLA
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X., Ge, J., Ye, G., Zhu, B., Zhang, Z., Kang, Y., Shan, X., Zhang, J."<p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>". International Journal of Molecular Medicine 57.4 (2026): 82.
Chicago
Liang, Y., Fan, X., Geng, X., Jia, Y., Shang, W., Sun, X., Ge, J., Ye, G., Zhu, B., Zhang, Z., Kang, Y., Shan, X., Zhang, J."<p>Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)</p>". International Journal of Molecular Medicine 57, no. 4 (2026): 82. https://doi.org/10.3892/ijmm.2026.5753
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