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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June-2026 Volume 57 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

  • Authors:
    • Yanming Wei
    • Kun Zhou
    • Yuerui Su
    • Zhihua Luan
    • Pengcheng Li
    • Yinxia Chang
    • Bo Han
    • Huifang Li
    • Yuanbiao Qiao
    • Jinhong Ren

  • View Affiliations / Copyright

    Affiliations: College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, Department of Energy Chemistry and Materials Engineering, Shanxi Institute of Energy, Taiyuan, Shanxi 030600, P.R. China, College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, Experimental Management Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, College of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, Experimental Management Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 142
    |
    Published online on: March 26, 2026
       https://doi.org/10.3892/ijmm.2026.5813
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Abstract

Ferroptosis is a novel form of regulated cell death triggered by iron‑dependent accumulation in lipid peroxidation. Multiple intracellular catabolic processes and signaling pathways are implicated in ferroptosis regulation. One is autophagy, which delivers cytoplasmic materials to lysosomes for degradation and is critical for the preservation of cellular homeostasis. The discovered role of autophagy in driving ferroptosis have motivated further explorations of the functional interactions and signal pathways between ferroptosis and autophagy, particularly their crosstalk in the pathogenesis or treatment for various liver diseases, such as drug‑induced liver injury, toxin‑induced liver injury, liver fibrosis and hepatocellular carcinoma. The present review presented an in‑depth overview of research on the crosstalk between autophagy and ferroptosis in diverse liver diseases, including the ones aforementioned. The diverse regulatory mechanisms involved in this process are also analyzed to open a new perspective on the interpretation of liver diseases manifestations and provide potential targets for drug discovery and effective intervene.

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Copy and paste a formatted citation
Spandidos Publications style
Wei Y, Zhou K, Su Y, Luan Z, Li P, Chang Y, Han B, Li H, Qiao Y, Ren J, Ren J, et al: Crosstalk between autophagy and ferroptosis in liver diseases (Review). Int J Mol Med 57: 142, 2026.
APA
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y. ... Ren, J. (2026). Crosstalk between autophagy and ferroptosis in liver diseases (Review). International Journal of Molecular Medicine, 57, 142. https://doi.org/10.3892/ijmm.2026.5813
MLA
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y., Han, B., Li, H., Qiao, Y., Ren, J."Crosstalk between autophagy and ferroptosis in liver diseases (Review)". International Journal of Molecular Medicine 57.6 (2026): 142.
Chicago
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y., Han, B., Li, H., Qiao, Y., Ren, J."Crosstalk between autophagy and ferroptosis in liver diseases (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 142. https://doi.org/10.3892/ijmm.2026.5813
Copy and paste a formatted citation
x
Spandidos Publications style
Wei Y, Zhou K, Su Y, Luan Z, Li P, Chang Y, Han B, Li H, Qiao Y, Ren J, Ren J, et al: Crosstalk between autophagy and ferroptosis in liver diseases (Review). Int J Mol Med 57: 142, 2026.
APA
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y. ... Ren, J. (2026). Crosstalk between autophagy and ferroptosis in liver diseases (Review). International Journal of Molecular Medicine, 57, 142. https://doi.org/10.3892/ijmm.2026.5813
MLA
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y., Han, B., Li, H., Qiao, Y., Ren, J."Crosstalk between autophagy and ferroptosis in liver diseases (Review)". International Journal of Molecular Medicine 57.6 (2026): 142.
Chicago
Wei, Y., Zhou, K., Su, Y., Luan, Z., Li, P., Chang, Y., Han, B., Li, H., Qiao, Y., Ren, J."Crosstalk between autophagy and ferroptosis in liver diseases (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 142. https://doi.org/10.3892/ijmm.2026.5813
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