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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June-2026 Volume 57 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Review Open Access

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

  • Authors:
    • Jing Mao
    • Mandi Luo
    • Lei Ruan
    • Cuntai Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 147
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    Published online on: March 31, 2026
       https://doi.org/10.3892/ijmm.2026.5818
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Abstract

Pyroptosis is a lytic and highly inflammatory type of programmed cell death that is mediated primarily by members of the gasdermin (GSDM) protein family. Upon activation by inflammatory stimuli or danger signals, GSDMs are cleaved to release N‑terminal fragments that oligomerize and form pores in the plasma membrane. This disrupts cellular integrity, resulting in osmotic lysis and the release of potent proinflammatory cytokines, such as interleukin (IL)‑1β and IL‑18. The progression of an aortic aneurysm (AA) is driven by complex pathophysiological processes, with the loss of vascular smooth muscle cells and sustained vascular inflammation being central to disease pathogenesis. Emerging evidence indicates that pyroptosis markedly contributes to AA development by amplifying inflammatory activation and promoting cellular disintegration within the aortic wall. Further preclinical evidence has demonstrated that pharmacological inhibition of key pyroptosis signaling pathways effectively attenuates AA formation in murine models, underscoring its promising therapeutic potential. The present review summarizes the molecular mechanisms of pyroptosis, highlights its pathophysiological role in AAs and discusses novel therapeutic strategies targeting pyroptosis for the treatment of AAs.

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Copy and paste a formatted citation
Spandidos Publications style
Mao J, Luo M, Ruan L and Zhang C: Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). Int J Mol Med 57: 147, 2026.
APA
Mao, J., Luo, M., Ruan, L., & Zhang, C. (2026). Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). International Journal of Molecular Medicine, 57, 147. https://doi.org/10.3892/ijmm.2026.5818
MLA
Mao, J., Luo, M., Ruan, L., Zhang, C."Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)". International Journal of Molecular Medicine 57.6 (2026): 147.
Chicago
Mao, J., Luo, M., Ruan, L., Zhang, C."Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 147. https://doi.org/10.3892/ijmm.2026.5818
Copy and paste a formatted citation
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Spandidos Publications style
Mao J, Luo M, Ruan L and Zhang C: Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). Int J Mol Med 57: 147, 2026.
APA
Mao, J., Luo, M., Ruan, L., & Zhang, C. (2026). Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review). International Journal of Molecular Medicine, 57, 147. https://doi.org/10.3892/ijmm.2026.5818
MLA
Mao, J., Luo, M., Ruan, L., Zhang, C."Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)". International Journal of Molecular Medicine 57.6 (2026): 147.
Chicago
Mao, J., Luo, M., Ruan, L., Zhang, C."Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)". International Journal of Molecular Medicine 57, no. 6 (2026): 147. https://doi.org/10.3892/ijmm.2026.5818
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