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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July-2026 Volume 58 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

  • Authors:
    • Chenglin Lu
    • Xiangyu Qi
    • Yuting Tong
    • Peng Lu
    • Dandan Luo
    • Qingbo Guan
    • Chunxiao Yu

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250001, P.R. China, Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan, Shandong 250001, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 190
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    Published online on: May 14, 2026
       https://doi.org/10.3892/ijmm.2026.5861
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Abstract

Autophagy is an evolutionarily conserved catabolic process in which excessive nutrients, toxic protein aggregates, damaged organelles, and invading microorganisms in the cytoplasm can be isolated by the double‑membrane structure of autophagosomes and delivered to lysosomes for degradation. Over the past two decades, research on autophagy has made significant progress. Autophagy not only plays a crucial role in maintaining intracellular homeostasis but also contributes to the development of various metabolic diseases. Metabolic imbalance of nutrients in obesity‑related metabolic diseases can interfere with the autophagy process through a variety of mechanisms, resulting in further aggravation of the pathological damage of related organs. However, under certain conditions, inhibition of autophagy can have beneficial effects, thereby alleviating some of the harmful consequences of obesity. In this review, we will focus on the latest advances in the study of autophagy in obesity‑related metabolic disorders, including type 2 diabetes, non‑alcoholic fatty liver disease, and atherosclerosis. We will systematically discuss the definition and types of autophagy, the regulation of autophagy by nutrients, the imbalance of autophagy in obesity‑related metabolic diseases and its molecular mechanism, and finally, we will summarize some drugs targeting the autophagy pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Lu C, Qi X, Tong Y, Lu P, Luo D, Guan Q and Yu C: Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review). Int J Mol Med 58: 190, 2026.
APA
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., & Yu, C. (2026). Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review). International Journal of Molecular Medicine, 58, 190. https://doi.org/10.3892/ijmm.2026.5861
MLA
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., Yu, C."Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)". International Journal of Molecular Medicine 58.1 (2026): 190.
Chicago
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., Yu, C."Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)". International Journal of Molecular Medicine 58, no. 1 (2026): 190. https://doi.org/10.3892/ijmm.2026.5861
Copy and paste a formatted citation
x
Spandidos Publications style
Lu C, Qi X, Tong Y, Lu P, Luo D, Guan Q and Yu C: Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review). Int J Mol Med 58: 190, 2026.
APA
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., & Yu, C. (2026). Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review). International Journal of Molecular Medicine, 58, 190. https://doi.org/10.3892/ijmm.2026.5861
MLA
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., Yu, C."Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)". International Journal of Molecular Medicine 58.1 (2026): 190.
Chicago
Lu, C., Qi, X., Tong, Y., Lu, P., Luo, D., Guan, Q., Yu, C."Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)". International Journal of Molecular Medicine 58, no. 1 (2026): 190. https://doi.org/10.3892/ijmm.2026.5861
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