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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September-2026 Volume 58 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

  • Authors:
    • Ruoxin Ren
    • Chunxiao Yan
    • Yao Xiang
    • Lin Jin
    • Fang Cheng
    • Lijun Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China, Department of Pharmaceutical Sciences, State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116081, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 240
    |
    Published online on: July 1, 2026
       https://doi.org/10.3892/ijmm.2026.5911
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Abstract

Zinc finger E‑box binding homeobox 1 (ZEB1), a key transcription factor governing epithelial‑mesenchymal transition, plays indispensable roles in embryonic development, neural differentiation and a wide range of pathological processes. Emerging evidence has revealed that ZEB1 exerts multifaceted and context‑dependent functions in angiogenesis. Under physiological conditions, ZEB1 contributes to the regulation of vascular development and endothelial homeostasis, whereas in pathological settings it promotes aberrant neovascularization through diverse molecular mechanisms. In the present review, the structural characteristics, biological functions and regulatory mechanisms of ZEB1 were systematically summarized, with a particular focus on recent advances regarding its roles in both physiological and pathological angiogenesis. Furthermore, the therapeutic potential of targeting ZEB1 in vascular diseases was discussed and future research directions that may facilitate the development of novel strategies for the prevention and treatment of angiogenesis‑related disorders were highlighted.

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Copy and paste a formatted citation
Spandidos Publications style
Ren R, Yan C, Xiang Y, Jin L, Cheng F and Zhang L: Role of ZEB1 in angiogenesis and therapeutic potential (Review). Int J Mol Med 58: 240, 2026.
APA
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., & Zhang, L. (2026). Role of ZEB1 in angiogenesis and therapeutic potential (Review). International Journal of Molecular Medicine, 58, 240. https://doi.org/10.3892/ijmm.2026.5911
MLA
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., Zhang, L."Role of ZEB1 in angiogenesis and therapeutic potential (Review)". International Journal of Molecular Medicine 58.3 (2026): 240.
Chicago
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., Zhang, L."Role of ZEB1 in angiogenesis and therapeutic potential (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 240. https://doi.org/10.3892/ijmm.2026.5911
Copy and paste a formatted citation
x
Spandidos Publications style
Ren R, Yan C, Xiang Y, Jin L, Cheng F and Zhang L: Role of ZEB1 in angiogenesis and therapeutic potential (Review). Int J Mol Med 58: 240, 2026.
APA
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., & Zhang, L. (2026). Role of ZEB1 in angiogenesis and therapeutic potential (Review). International Journal of Molecular Medicine, 58, 240. https://doi.org/10.3892/ijmm.2026.5911
MLA
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., Zhang, L."Role of ZEB1 in angiogenesis and therapeutic potential (Review)". International Journal of Molecular Medicine 58.3 (2026): 240.
Chicago
Ren, R., Yan, C., Xiang, Y., Jin, L., Cheng, F., Zhang, L."Role of ZEB1 in angiogenesis and therapeutic potential (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 240. https://doi.org/10.3892/ijmm.2026.5911
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