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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September-2026 Volume 58 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

  • Authors:
    • Mingxia Zhang
    • Yuting Pu
    • Yujie Zhang
    • Jia Hu
    • Shuangyang Li
    • Hongmei Tang
    • Bangjiang Fang
    • Xue Bai

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646600, P.R. China, College of Integrated Traditional and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646600, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 244
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    Published online on: July 2, 2026
       https://doi.org/10.3892/ijmm.2026.5915
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Abstract

Migraines are highly prevalent and disabling neurological disorders. Central sensitisation constitutes the core pathophysiological basis for its recurrent and chronic nature. Transient receptor potential vanilloid 1 (TRPV1), a key molecule in pain signalling, is not only involved in peripheral nociception, but is also highly expressed in central pain‑processing regions. TRPV1 directly contributes to the initiation and maintenance of central sensitisation, positioning it as a promising therapeutic target for migraine management. The present review systematically summarised the biological characteristics of TRPV1 and its associations with central sensitisation and migraines. The molecular mechanisms through which TRPV1 mediates central sensitisation are elaborated upon, including the regulation of neurotransmitter release, activation of glial cells, involvement in inflammatory responses and modulation of synaptic plasticity. Furthermore, the research progress and clinical challenges of TRPV1‑targeted strategies are discussed, including antagonists, agonists and genetic regulation. Lastly, the present study proposes future research directions at both basic and clinical levels, providing a novel molecular perspective on migraine pathogenesis and establishing a theoretical foundation for the development of targeted clinical therapies.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Pu Y, Zhang Y, Hu J, Li S, Tang H, Fang B and Bai X: TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review). Int J Mol Med 58: 244, 2026.
APA
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H. ... Bai, X. (2026). TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review). International Journal of Molecular Medicine, 58, 244. https://doi.org/10.3892/ijmm.2026.5915
MLA
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H., Fang, B., Bai, X."TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)". International Journal of Molecular Medicine 58.3 (2026): 244.
Chicago
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H., Fang, B., Bai, X."TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 244. https://doi.org/10.3892/ijmm.2026.5915
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Pu Y, Zhang Y, Hu J, Li S, Tang H, Fang B and Bai X: TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review). Int J Mol Med 58: 244, 2026.
APA
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H. ... Bai, X. (2026). TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review). International Journal of Molecular Medicine, 58, 244. https://doi.org/10.3892/ijmm.2026.5915
MLA
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H., Fang, B., Bai, X."TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)". International Journal of Molecular Medicine 58.3 (2026): 244.
Chicago
Zhang, M., Pu, Y., Zhang, Y., Hu, J., Li, S., Tang, H., Fang, B., Bai, X."TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)". International Journal of Molecular Medicine 58, no. 3 (2026): 244. https://doi.org/10.3892/ijmm.2026.5915
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