[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Following the publication of the above article, an interested reader drew to the authors’ attention that the COX IV western blot data shown in Fig. 3D on p. 611 were strikingly similar to blots that appeared in another article by the same research group that was published in the journal Molecular Medicine Reports. In addition, it was noted that a section of the fluorescence microscopic data shown in Fig. 4A (in the “Adpa‑Mn 20 μM + 3‑MA” data panel) bore a strong resemblance to the data shown in Fig. 5A for the “Adpa‑Mn 20 μM” experiment. Thirdly, concerns were raised regarding the tumour images shown in Fig. 6A. Certain of the tumours appeared rather large, although a corresponding scale alongside the tumours was not shown in the figure; in addition, the tumour weights reported in Fig. 6B appeared not to be commensurate with the apparent sizes of the tumours, and Fig. 6B showed quantification of the data for three different Adpa‑Mn treatment groups (1 mg/kg, 5 mg/kg and 10 mg/kg), whereas only tumours from the 10 mg/kg group were portrayed in Fig. 6A. Upon re‑examining the raw data belonging to these figures, due to oversights that were made during the final assembly and handling of a large volume of experimental data, the authors realize that some errors were inadvertently made in assembling the data in various of the figures. In Fig. 3, the western blot band for the COX IV loading control was misused, and an incorrect band was included in this figure. In Figs. 4 and 5, certain fluorescence microscopy images were misplaced during the final preparation, leading to the incorrect placement of the data panel in Fig. 4A. Finally, in Fig. 6A, the tumour images for the 1 mg/kg and 5 mg/kg treatment groups had not originally been included, and a scale bar was omitted from Fig. 6A. Concerning the animal experiments, the Editor permitted the authors to repeat the in vivo experiments under rigorous conditions, and in the new version of Fig. 6, a complete set of tumour photographs for all groups has been provided, now including a scale bar. The revised versions of Fig. 3 (showing the correct data for the COX IV western blots in Fig. 3D) and Fig. 4 (showing the correct data for the “Adpa‑Mn 20 μM + 3‑MA” panel in Fig. 4A), and the new version of Fig. 6, are shown on the subsequent pages. Note that the errors made during the assembly of these figures did not affect the overall conclusions reported in the paper. All the authors agree with the publication of this corrigendum, and are grateful to the Editor of International Journal of Molecular Medicine for allowing them the opportunity to publish this. They also apologize to the readership for any inconvenience caused. [International Journal of Molecular Medicine 35: 607‑616, 2015; DOI: 10.3892/ijmm.2015.2073]