Targeting ferroptosis in metabolic dysfunction‑associated steatotic liver disease: From mechanisms to cell type‑specific therapeutic strategies (Review)

Tao,Xiang; Liu,Mei

doi:10.3892/ijmm.2026.6028

December-2026 Volume 58 Issue 6

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December-2026 Volume 58 Issue 6

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Targeting ferroptosis in metabolic dysfunction‑associated steatotic liver disease: From mechanisms to cell type‑specific therapeutic strategies (Review)

Authors:
- Xiang Tao
- Mei Liu
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China

Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 357
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Published online on: October 26, 2026

https://doi.org/10.3892/ijmm.2026.6028
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Abstract

Metabolic dysfunction‑associated steatotic liver disease (MASLD) impacts >30% of the global population. Its progression to metabolic dysfunction‑associated steatohepatitis and liver fibrosis is the primary determinant for cirrhosis and hepatocellular carcinoma. Ferroptosis depends on iron and is driven by lipid peroxidation and is involved in the development of MASLD. Effective anti‑fibrotic agents remain an unmet clinical need. The present review aimed to summarize the metabolic environment in MASLD, which is characterized by lipid overload, iron dysregulation and oxidative stress, and its role in facilitating ferroptosis using a cell type‑ and disease stage‑specific framework, integrating intercellular crosstalk and evidence grading for biomarkers and therapeutic agents, as well as knowledge gaps, such as the paucity of direct human evidence, unresolved spatiotemporal dynamics and the necessity for precision delivery systems. The present review positions ferroptosis as a key pathophysiological element in MASLD and a promising frontier for diagnostic and therapeutic innovation by combining mechanistic insight with translational perspectives.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Targeting ferroptosis in metabolic dysfunction‑associated steatotic liver disease: From mechanisms to cell type‑specific therapeutic strategies (Review)

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