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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December-2026 Volume 58 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review)

  • Authors:
    • Weihua Zheng
    • Caiyan An
    • Long Xia
    • Hongquan Wang
    • Yumin Wang
    • Junjing Zhang

  • View Affiliations / Copyright

    Affiliations: Inner Mongolia Key Laboratory of Allergic Diseases, Foundational and Translational Medical Research Center, Department of Allergy and General Surgery, Hohhot First Hospital, Hohhot, Inner Mongolia Autonomous Region 010030, P.R. China, Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 358
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    Published online on: October 27, 2026
       https://doi.org/10.3892/ijmm.2026.6029
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Abstract

Metabolic dysfunction‑associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide and a leading cause of liver‑related morbidity and mortality. MASLD encompasses a pathological spectrum ranging from metabolic dysfunction‑associated steatohepatitis to cirrhosis and hepatocellular carcinoma (HCC), making it the fastest‑growing contributor to the global incidence of HCC. Non‑coding RNAs (ncRNAs), once regarded as ‘genomic dark matter’, are increasingly recognised as key regulatory molecules in a variety of liver diseases. However, their systematic involvement in the malignant progression from MASLD to HCC remains incompletely understood. Emerging evidence suggests that ncRNAs play critical roles in modulating the major pathophysiological processes underlying MASLD‑driven HCC progression, including dysregulated lipid metabolism, chronic inflammation, oxidative stress, immune imbalance and gut microbiota disruption. The present review systematically examines the specific functions of major ncRNA classes, including microRNAs, long ncRNAs and circular RNAs, in the pathogenesis of MASLD‑driven HCC. In addition, given their considerable diagnostic and therapeutic potential, the present review evaluates the prospects of ncRNAs as novel biomarkers and therapeutic targets to facilitate the early detection and precision treatment of MASLD‑driven HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Zheng W, An C, Xia L, Wang H, Wang Y and Zhang J: Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review). Int J Mol Med 58: 358, 2026.
APA
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., & Zhang, J. (2026). Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review). International Journal of Molecular Medicine, 58, 358. https://doi.org/10.3892/ijmm.2026.6029
MLA
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., Zhang, J."Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review)". International Journal of Molecular Medicine 58.6 (2026): 358.
Chicago
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., Zhang, J."Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review)". International Journal of Molecular Medicine 58, no. 6 (2026): 358. https://doi.org/10.3892/ijmm.2026.6029
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, An C, Xia L, Wang H, Wang Y and Zhang J: Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review). Int J Mol Med 58: 358, 2026.
APA
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., & Zhang, J. (2026). Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review). International Journal of Molecular Medicine, 58, 358. https://doi.org/10.3892/ijmm.2026.6029
MLA
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., Zhang, J."Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review)". International Journal of Molecular Medicine 58.6 (2026): 358.
Chicago
Zheng, W., An, C., Xia, L., Wang, H., Wang, Y., Zhang, J."Emerging role of non‑coding RNAs in the progression of MASLD‑driven hepatocellular carcinoma (Review)". International Journal of Molecular Medicine 58, no. 6 (2026): 358. https://doi.org/10.3892/ijmm.2026.6029
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