Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies

  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2027 Volume 59 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2027 Volume 59 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
Review Open Access

Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review)

  • Authors:
    • Hanlu Chen
    • Tao Ding
    • Yifan Zhu
    • Mei Yang
    • Fangsheng Wang
    • Puwen Chen
    • Haihong Lin
    • Huapei Kang
    • Maohong Hu
    • Jun Zhou
    • Xiaoling Wang

  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, The First School of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, College of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, Department of Laboratory Medicine, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou 550000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 4
    |
    Published online on: November 12, 2026
       https://doi.org/10.3892/ijmm.2026.6051
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Metabolic syndrome (MetS) is associated with increased risk of Alzheimer's disease (AD), however, the majority of previous studies regard MetS as an isolated risk factor and focus on single pathways, lacking systematic understanding of combined effects among multiple metabolic components. The present review systematically summarizes the multifaceted mechanisms by which MetS promotes AD pathology, including insulin resistance and cerebral energy dysregulation, oxidative stress and mitochondrial dysfunction, neuroinflammation and glial cell activation, vascular dysfunction and dysregulation of the renin‑angiotensin system, as well as the central convergent signaling pathway involving glycogen synthase kinase‑3β. The present review further highlights emerging regulatory mechanisms involving the gut‑brain axis, epigenetic reprogramming, sex differences and hormonal effects and senescent microenvironment. By emphasizing the peripheral‑central crosstalk and interactive amplification of MetS components, the present review aimed to position AD as a central manifestation of systemic metabolic disorders in the brain and propose a multi‑domain precision strategy integrating lifestyle intervention, metabolic drug repurposing, gut microbiota regulation, anti‑aging therapy and biomarker‑guided subtype classification for intervention against MetS‑associated AD.

Related Articles

  • Abstract
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen H, Ding T, Zhu Y, Yang M, Wang F, Chen P, Lin H, Kang H, Hu M, Zhou J, Zhou J, et al: Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review). Int J Mol Med 59: 4, 2027.
APA
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P. ... Wang, X. (2027). Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review). International Journal of Molecular Medicine, 59, 4. https://doi.org/10.3892/ijmm.2026.6051
MLA
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P., Lin, H., Kang, H., Hu, M., Zhou, J., Wang, X."Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review)". International Journal of Molecular Medicine 59.1 (2027): 4.
Chicago
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P., Lin, H., Kang, H., Hu, M., Zhou, J., Wang, X."Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review)". International Journal of Molecular Medicine 59, no. 1 (2027): 4. https://doi.org/10.3892/ijmm.2026.6051
Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Ding T, Zhu Y, Yang M, Wang F, Chen P, Lin H, Kang H, Hu M, Zhou J, Zhou J, et al: Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review). Int J Mol Med 59: 4, 2027.
APA
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P. ... Wang, X. (2027). Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review). International Journal of Molecular Medicine, 59, 4. https://doi.org/10.3892/ijmm.2026.6051
MLA
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P., Lin, H., Kang, H., Hu, M., Zhou, J., Wang, X."Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review)". International Journal of Molecular Medicine 59.1 (2027): 4.
Chicago
Chen, H., Ding, T., Zhu, Y., Yang, M., Wang, F., Chen, P., Lin, H., Kang, H., Hu, M., Zhou, J., Wang, X."Metabolic syndrome and Alzheimer's disease: Mechanistic links and precision prevention (Review)". International Journal of Molecular Medicine 59, no. 1 (2027): 4. https://doi.org/10.3892/ijmm.2026.6051
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team