Messenger RNA expression profiling using DNA microarray technology: Diagnostic tool, scientific analysis or un-interpretable data? (Review)

  • Authors:
    • Moira S. Walker
    • Thomas A. Hughes
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/ijmm.21.1.13
  • Pages: 13-17
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Analysis of the transcriptome using DNA microarrays has become a standard approach for investigation of the molecular basis of human disease in both clinical and experimental settings. However, drawing conclusions from the wealth of data obtained has remained problematic. There have been difficulties with accurate reporting of results, with experimental reproducibility and with identifying and interpreting the biologically relevant information. In this review we discuss the successful use of DNA microarray technology in molecular medical research, and we highlight methods of addressing the issues of both reproducibility and biological interpretation.

Related Articles

Journal Cover

January 2008
Volume 21 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Walker MS and Walker MS: Messenger RNA expression profiling using DNA microarray technology: Diagnostic tool, scientific analysis or un-interpretable data? (Review). Int J Mol Med 21: 13-17, 2008
APA
Walker, M.S., & Walker, M.S. (2008). Messenger RNA expression profiling using DNA microarray technology: Diagnostic tool, scientific analysis or un-interpretable data? (Review). International Journal of Molecular Medicine, 21, 13-17. https://doi.org/10.3892/ijmm.21.1.13
MLA
Walker, M. S., Hughes, T. A."Messenger RNA expression profiling using DNA microarray technology: Diagnostic tool, scientific analysis or un-interpretable data? (Review)". International Journal of Molecular Medicine 21.1 (2008): 13-17.
Chicago
Walker, M. S., Hughes, T. A."Messenger RNA expression profiling using DNA microarray technology: Diagnostic tool, scientific analysis or un-interpretable data? (Review)". International Journal of Molecular Medicine 21, no. 1 (2008): 13-17. https://doi.org/10.3892/ijmm.21.1.13