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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2008 Volume 21 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

A novel activation-induced suicidal degradation mechanism for Akt by selenium

  • Authors:
    • Ji-Hyun Lee
    • Sun Hye Shin
    • Seongman Kang
    • Yun-Sil Lee
    • Sangwoo Bae
  • View Affiliations / Copyright

    Affiliations: Laboratory of Modulation of Radiobiological Responses, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea
  • Pages: 91-97
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/ijmm.21.1.91
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Abstract

Selenium has been associated with an anti-cancer effect via the modulation of Akt. In order to investigate whether selenium modulates Akt by hitherto unidentified molecular mechanisms, we examined the effect of selenium on the stability and activity of Akt. Selenium induced destabilization of Akt which is coupled to its own enzyme activation. Mutation of T308 and S473 of Akt to alanine as well as the inhibition or depletion of upstream kinases for Akt activation blocked Akt degradation. These features of Akt degradation are reminiscent of the ‘activation-induced suicidal degradation’ mechanism. PTEN was also required for Akt destabilization as Akt activation alone was unable to elicit Akt degradation in the absence of PTEN. Conversely, PTEN introduction in PTEN-null prostate cancer cells restored the ability to degrade Akt upon selenium treatment. Collectively, selenium seems to achieve ultimate negative regulation of Akt signaling by destabilizing the protein, and this regulation mechanism might provide a paradigm for the anti-cancer activity of selenium.

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Copy and paste a formatted citation
Spandidos Publications style
Lee J, Shin SH, Kang S, Lee Y and Bae S: A novel activation-induced suicidal degradation mechanism for Akt by selenium. Int J Mol Med 21: 91-97, 2008.
APA
Lee, J., Shin, S.H., Kang, S., Lee, Y., & Bae, S. (2008). A novel activation-induced suicidal degradation mechanism for Akt by selenium. International Journal of Molecular Medicine, 21, 91-97. https://doi.org/10.3892/ijmm.21.1.91
MLA
Lee, J., Shin, S. H., Kang, S., Lee, Y., Bae, S."A novel activation-induced suicidal degradation mechanism for Akt by selenium". International Journal of Molecular Medicine 21.1 (2008): 91-97.
Chicago
Lee, J., Shin, S. H., Kang, S., Lee, Y., Bae, S."A novel activation-induced suicidal degradation mechanism for Akt by selenium". International Journal of Molecular Medicine 21, no. 1 (2008): 91-97. https://doi.org/10.3892/ijmm.21.1.91
Copy and paste a formatted citation
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Spandidos Publications style
Lee J, Shin SH, Kang S, Lee Y and Bae S: A novel activation-induced suicidal degradation mechanism for Akt by selenium. Int J Mol Med 21: 91-97, 2008.
APA
Lee, J., Shin, S.H., Kang, S., Lee, Y., & Bae, S. (2008). A novel activation-induced suicidal degradation mechanism for Akt by selenium. International Journal of Molecular Medicine, 21, 91-97. https://doi.org/10.3892/ijmm.21.1.91
MLA
Lee, J., Shin, S. H., Kang, S., Lee, Y., Bae, S."A novel activation-induced suicidal degradation mechanism for Akt by selenium". International Journal of Molecular Medicine 21.1 (2008): 91-97.
Chicago
Lee, J., Shin, S. H., Kang, S., Lee, Y., Bae, S."A novel activation-induced suicidal degradation mechanism for Akt by selenium". International Journal of Molecular Medicine 21, no. 1 (2008): 91-97. https://doi.org/10.3892/ijmm.21.1.91
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