Enhancement of XPG mRNA transcription by human interferon-beta in Cockayne syndrome cells with complementation group B.

  • Authors:
    • Y Suzuki
    • K Sugita
    • N Suzuki
    • K Kita
    • Y Higuchi
    • A Yamaura
    • Y Kohno
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijmm.3.1.87
  • Pages: 87-96
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Abstract

Human interferon-beta (HuIFN-beta) confers UV-refractoriness in association with increased DNA repair capacity to human cells. We examined the modulation of XPG gene expression by HuIFN-beta in UV-sensitive cells from Cockayne syndrome complementation B (CSB), xeroderma pigmentosum complementation A (XPA) and normal control cells. Northern blot analysis revealed that XPG mRNA was more extensively transcribed in CSB cells treated with HuIFN-beta than in those without HuIFN-beta treatment. XPG mRNA from XPA cells and normal control cells was not markedly transcribed by HuIFN-beta treatment compared to that from CSB cells. The findings suggested that different mechanisms of UV-refractoriness by HuIFN-beta exist between CS and XP.

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Jan 1999
Volume 3 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Suzuki Y, Sugita K, Suzuki N, Kita K, Higuchi Y, Yamaura A and Kohno Y: Enhancement of XPG mRNA transcription by human interferon-beta in Cockayne syndrome cells with complementation group B.. Int J Mol Med 3: 87-96, 1999
APA
Suzuki, Y., Sugita, K., Suzuki, N., Kita, K., Higuchi, Y., Yamaura, A., & Kohno, Y. (1999). Enhancement of XPG mRNA transcription by human interferon-beta in Cockayne syndrome cells with complementation group B.. International Journal of Molecular Medicine, 3, 87-96. https://doi.org/10.3892/ijmm.3.1.87
MLA
Suzuki, Y., Sugita, K., Suzuki, N., Kita, K., Higuchi, Y., Yamaura, A., Kohno, Y."Enhancement of XPG mRNA transcription by human interferon-beta in Cockayne syndrome cells with complementation group B.". International Journal of Molecular Medicine 3.1 (1999): 87-96.
Chicago
Suzuki, Y., Sugita, K., Suzuki, N., Kita, K., Higuchi, Y., Yamaura, A., Kohno, Y."Enhancement of XPG mRNA transcription by human interferon-beta in Cockayne syndrome cells with complementation group B.". International Journal of Molecular Medicine 3, no. 1 (1999): 87-96. https://doi.org/10.3892/ijmm.3.1.87