Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.

  • Authors:
    • R Shimano
    • R Inubushi
    • A Adachi
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/ijmm.3.1.91
  • Pages: 91-95
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Abstract

We have previously shown that some gag gene mutants of human immunodeficiency virus type 1 (HIV-1) display a replication-defect in a cell-dependent manner. We and others have also demonstrated that the requirement of vif and vpu genes for HIV-1 replication is cell-dependent. To determine whether the cell-dependent growth of the HIV-1 gag mutants is related to the functions of Vif and Vpu, double mutants of gag-vif and gag-vpu were constructed, and monitored for their replication in various cell lines. The results obtained showed that the mutations in gag do not affect the cell-dependent functions of Vif and Vpu.

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Jan 1999
Volume 3 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Shimano R, Inubushi R and Adachi A: Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.. Int J Mol Med 3: 91-95, 1999
APA
Shimano, R., Inubushi, R., & Adachi, A. (1999). Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.. International Journal of Molecular Medicine, 3, 91-95. https://doi.org/10.3892/ijmm.3.1.91
MLA
Shimano, R., Inubushi, R., Adachi, A."Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.". International Journal of Molecular Medicine 3.1 (1999): 91-95.
Chicago
Shimano, R., Inubushi, R., Adachi, A."Host cell-dependent replication of HIV-1 gag MA, CA, and NC mutants are independent of the functions of Vif and Vpu.". International Journal of Molecular Medicine 3, no. 1 (1999): 91-95. https://doi.org/10.3892/ijmm.3.1.91