Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma.

  • Authors:
    • T Nishi
    • J Kuratsu
    • H Takeshima
    • Y Saito
    • M Kochi
    • Y Ushio
  • View Affiliations

  • Published online on: February 1, 1999     https://doi.org/10.3892/ijmm.3.2.157
  • Pages: 157-218
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Abstract

Proliferative activity of 17 craniopharyngiomas were determined using an immunohistochemical method with monoclonal antibody MIB-1. A considerable variation of the MIB-1 labeling indices was found between the different tumors with a minimum of 0.4% and a maximum of 32.5% (median, 10.84%). The mean MIB-1 labeling index (LI) for 4 craniopharyngiomas that showed no evidence of recurrence (n=4) was 3.4 +/- 2.3%. This was significantly lower than that for craniopharyngiomas that showed recurrence and regrowth (13.2 +/- 7.7%) (n=13), based on the initial resected tumors. Statistical analysis reveal that craniopharyngiomas with an MIB-1 LI of 7% or more have a significantly high tendency for recurrence and regrowth during clinical course. Our data suggest that a MIB-1 LI greater than 7% may be a useful predictor of regrowth/recurrence of craniopharyngiomas and may be useful for planning of adjuvant therapy.

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Feb 1999
Volume 3 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nishi T, Kuratsu J, Takeshima H, Saito Y, Kochi M and Ushio Y: Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma.. Int J Mol Med 3: 157-218, 1999
APA
Nishi, T., Kuratsu, J., Takeshima, H., Saito, Y., Kochi, M., & Ushio, Y. (1999). Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma.. International Journal of Molecular Medicine, 3, 157-218. https://doi.org/10.3892/ijmm.3.2.157
MLA
Nishi, T., Kuratsu, J., Takeshima, H., Saito, Y., Kochi, M., Ushio, Y."Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma.". International Journal of Molecular Medicine 3.2 (1999): 157-218.
Chicago
Nishi, T., Kuratsu, J., Takeshima, H., Saito, Y., Kochi, M., Ushio, Y."Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma.". International Journal of Molecular Medicine 3, no. 2 (1999): 157-218. https://doi.org/10.3892/ijmm.3.2.157