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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May 1999 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1999 Volume 3 Issue 5

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Article

Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).

  • Authors:
    • J Golab
    • R Zagozdzon
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Institute of Biostructure, Medical University of Warsaw, 02-004 Warsaw, Poland.
  • Pages: 537-581
    |
    Published online on: May 1, 1999
       https://doi.org/10.3892/ijmm.3.5.537
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Abstract

Interleukin-12 (IL-12) previously called cytotoxic lymphocyte maturation factor (CLMF) or NK cell stimulatory factor (NKSF) is a recently characterized heterodimeric cytokine composed of two subunits. Although identified no more than 10 years ago IL-12 has already proved efficacious in numerous pre-clinical tumor immunotherapy studies. Animal studies revealed that IL-12 has powerful antitumor, anti-metastatic and anti-angiogenic activities and seems to be less toxic than other immunotherapeutics such as interferons or IL-2. A number of pre-clinical studies with IL-12 prompted the evaluation of this cytokine in the treatment of human cancers. Results of phase I and early phase II clinical trials have already been reported and these are described here together with a brief discussion concerning IL-12-related toxicities and potential methods of their prevention.

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Copy and paste a formatted citation
Spandidos Publications style
Golab J and Zagozdzon R: Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).. Int J Mol Med 3: 537-581, 1999.
APA
Golab, J., & Zagozdzon, R. (1999). Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).. International Journal of Molecular Medicine, 3, 537-581. https://doi.org/10.3892/ijmm.3.5.537
MLA
Golab, J., Zagozdzon, R."Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).". International Journal of Molecular Medicine 3.5 (1999): 537-581.
Chicago
Golab, J., Zagozdzon, R."Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).". International Journal of Molecular Medicine 3, no. 5 (1999): 537-581. https://doi.org/10.3892/ijmm.3.5.537
Copy and paste a formatted citation
x
Spandidos Publications style
Golab J and Zagozdzon R: Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).. Int J Mol Med 3: 537-581, 1999.
APA
Golab, J., & Zagozdzon, R. (1999). Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).. International Journal of Molecular Medicine, 3, 537-581. https://doi.org/10.3892/ijmm.3.5.537
MLA
Golab, J., Zagozdzon, R."Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).". International Journal of Molecular Medicine 3.5 (1999): 537-581.
Chicago
Golab, J., Zagozdzon, R."Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).". International Journal of Molecular Medicine 3, no. 5 (1999): 537-581. https://doi.org/10.3892/ijmm.3.5.537
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