T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review).

Fleury,S; Pantaleo,G

doi:10.3892/ijmm.4.1.91

Jul 1999 Volume 4 Issue 1

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Jul 1999 Volume 4 Issue 1

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Article

T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review).

Authors:
- S Fleury
- G Pantaleo
View Affiliations / Copyright

Affiliations: Laboratory of AIDS Immunopathogenesis, Department of Medicine, Division of Infectious Diseases, CH-1011 Lausanne, Switzerland.
Pages: 91-98
|
Published online on: July 1, 1999

https://doi.org/10.3892/ijmm.4.1.91
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Abstract

The initial idea that high amounts of cytopathic virus produced everyday can drive high CD4+ T cell production seemed logical and explained the progressive CD4+ T cell depletion observed in HIV-infected subjects. It was hypothesized that the CD4+ T lymphocyte production was increased up to 70-fold in HIV-infected subjects. Determination of the CD4+ T cell production was based on the kinetics of CD4+ T cell recovery following initiation of highly active antiretroviral therapy (HAART). However, this analysis is limited by: i) the assumption that blood CD4+ T cells are representative of the lymph node T cells; and ii) the lack of estimates of CD4+ T lymphocyte turnover in healthy HIV-negative subjects. Several immunologists have expressed caution regarding the assumptions used in modeling CD4+ T cell dynamics. Recent findings clearly show that blood is not representative of lymphoid tissues and invalidate the conclusion of high CD4 turnover drawn from blood studies on HIV-infected subjects. Indeed, when blood and lymph node compartments are considered together, we find that HIV-infected subjects naive to antiretroviral have similar or lower CD4+ T cell production, as compared to healthy subjects. This observation suggests an impaired T cell renewal capacity in HIV-1 infected patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review).

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Abstract

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