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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Aug 1999 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Aug 1999 Volume 4 Issue 2

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Article

Proliferative and apoptotic activity in lobular breast carcinoma.

  • Authors:
    • S Krüger
    • T Fahrenkrog
    • H Müller

  • View Affiliations / Copyright

    Affiliations: Institut für Pathologie, Medizinische Universität zu Lübeck, D-23538 Lübeck, Germany.
  • Pages: 171-175
    |
    Published online on: August 1, 1999
       https://doi.org/10.3892/ijmm.4.2.171
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Abstract

Apoptotic and proliferative activity was studied in 25 invasive lobular breast carcinomas (ILC), and the relationship with conventional prognostic parameters [tumor size, nodal status, expression of estrogen (ER) and progesterone receptors (PR)] was investigated. Also 12 lobular carcinomata in situ (LCIS), 25 invasive ductal carcinomas (IDC) and 12 normal breast tissue controls were included. MIB-1 growth fraction (GF), mitotic index (MI) and the number of argyrophilic nucleolar organizer regions (AgNOR) served as proliferative parameters. Apoptotic index (AI) was determined after visualization of apoptoses by the TUNEL method. All parameters increased in the following order: control tissue - LCIS - ILC - IDC. Except for a negative correlation between GF and ER expression, no other significant relationship between any of the kinetical parameters and any prognostic parameter could be found in ILC. However, a significant inverse correlation between the GF:AI ratio and both ER and PR expression was registered. We conclude from our results a) that transition from non-invasive to invasive growth in lobular breast cancer is associated with an increased cellular turnover, and b) that proliferative activity is significantly lower in ILC than in IDC. The GF:AI ratio may possibly provide additional prognostic information in lobular breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Krüger S, Fahrenkrog T and Müller H: Proliferative and apoptotic activity in lobular breast carcinoma.. Int J Mol Med 4: 171-175, 1999.
APA
Krüger, S., Fahrenkrog, T., & Müller, H. (1999). Proliferative and apoptotic activity in lobular breast carcinoma.. International Journal of Molecular Medicine, 4, 171-175. https://doi.org/10.3892/ijmm.4.2.171
MLA
Krüger, S., Fahrenkrog, T., Müller, H."Proliferative and apoptotic activity in lobular breast carcinoma.". International Journal of Molecular Medicine 4.2 (1999): 171-175.
Chicago
Krüger, S., Fahrenkrog, T., Müller, H."Proliferative and apoptotic activity in lobular breast carcinoma.". International Journal of Molecular Medicine 4, no. 2 (1999): 171-175. https://doi.org/10.3892/ijmm.4.2.171
Copy and paste a formatted citation
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Spandidos Publications style
Krüger S, Fahrenkrog T and Müller H: Proliferative and apoptotic activity in lobular breast carcinoma.. Int J Mol Med 4: 171-175, 1999.
APA
Krüger, S., Fahrenkrog, T., & Müller, H. (1999). Proliferative and apoptotic activity in lobular breast carcinoma.. International Journal of Molecular Medicine, 4, 171-175. https://doi.org/10.3892/ijmm.4.2.171
MLA
Krüger, S., Fahrenkrog, T., Müller, H."Proliferative and apoptotic activity in lobular breast carcinoma.". International Journal of Molecular Medicine 4.2 (1999): 171-175.
Chicago
Krüger, S., Fahrenkrog, T., Müller, H."Proliferative and apoptotic activity in lobular breast carcinoma.". International Journal of Molecular Medicine 4, no. 2 (1999): 171-175. https://doi.org/10.3892/ijmm.4.2.171
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