Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.

  • Authors:
    • T Inomata
    • Y Ogawa
    • S Itoh
    • S Kariya
    • N Hamada
    • A Nishioka
    • S Yoshida
    • H Nagasawa
    • H Hori
    • S Inayama
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijmm.4.3.257
  • Pages: 257-317
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Abstract

KIN-806 is one of the newly developed 2-nitroimidazole derivative hypoxic cell radiosensitizers. The tumor growth control and the suppression of lung metastasis induced by KIN-806 were evaluated. Female C3H/He mice and SCCVII tumor cells were used. 30 Gy or 40 Gy was delivered as local irradiation. 0.2 g/kg or 0.4 g/kg KIN-806 was administered 30 min before this treatment to the KIN-806 administered groups. The enhancement ratio of KIN-806 evaluated using the growth delay method was 1.8. KIN-806 showed an excellent effect as a radiosensitizer. Furthermore, KIN-806 suppressed lung metastasis regardless of radiation, and the control of the metastatic lung nodules did not depend on the irradiation dose but rather on the KIN-806 dose (0.2 g/kg < 0.4 g/kg). KIN-806 is a promising bifunctional radiosensitizer which promotes anti-tumor activity in addition to having a radiosensitizing effect.

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Sep 1999
Volume 4 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Inomata T, Ogawa Y, Itoh S, Kariya S, Hamada N, Nishioka A, Yoshida S, Nagasawa H, Hori H, Inayama S, Inayama S, et al: Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.. Int J Mol Med 4: 257-317, 1999
APA
Inomata, T., Ogawa, Y., Itoh, S., Kariya, S., Hamada, N., Nishioka, A. ... Inayama, S. (1999). Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.. International Journal of Molecular Medicine, 4, 257-317. https://doi.org/10.3892/ijmm.4.3.257
MLA
Inomata, T., Ogawa, Y., Itoh, S., Kariya, S., Hamada, N., Nishioka, A., Yoshida, S., Nagasawa, H., Hori, H., Inayama, S."Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.". International Journal of Molecular Medicine 4.3 (1999): 257-317.
Chicago
Inomata, T., Ogawa, Y., Itoh, S., Kariya, S., Hamada, N., Nishioka, A., Yoshida, S., Nagasawa, H., Hori, H., Inayama, S."Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.". International Journal of Molecular Medicine 4, no. 3 (1999): 257-317. https://doi.org/10.3892/ijmm.4.3.257