Clinical implications of telomerase activity in resected hepatocellular carcinoma.

  • Authors:
    • T Kanamaru
    • M Yamamoto
    • Y Morita
    • T Itoh
    • Y Kuroda
    • H Hisatomi
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijmm.4.3.267
  • Pages: 267-338
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Abstract

This study investigated the relationship of telomerase activity to its clinical implications in hepatocellular carcinoma (HCC). Telomerase activity was quantatively examined by a non-radioisotope quantitative system based on a TRAP-eze (ONCOR) in 42 HCC nodules and 40 non-cancerous liver tissue adjacent to the HCC nodules, obtained by surgical resection. Telomerase activity was confirmed in 37 HCC nodules (88.1%), being more statistically intense in de-differentiated tumors (p<0.01). Telomerase activity was positive in 9 cases (22.5%) of non-cancerous liver tissue and its activation was closely associated with the biologically malignant potential of the tumor itself such as the histological grade, portal vascular invasion, and intrahepatic metastasis (p<0. 05). The disease-free survival rate with its activity was also statistically lower than that without its activity of the non-cancerous tissue (p<0.01). These results indicate that telomerase may be a useful marker of biological characteristics in HCC and may lead to more effective surgical procedures.

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Sep 1999
Volume 4 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kanamaru T, Yamamoto M, Morita Y, Itoh T, Kuroda Y and Hisatomi H: Clinical implications of telomerase activity in resected hepatocellular carcinoma.. Int J Mol Med 4: 267-338, 1999
APA
Kanamaru, T., Yamamoto, M., Morita, Y., Itoh, T., Kuroda, Y., & Hisatomi, H. (1999). Clinical implications of telomerase activity in resected hepatocellular carcinoma.. International Journal of Molecular Medicine, 4, 267-338. https://doi.org/10.3892/ijmm.4.3.267
MLA
Kanamaru, T., Yamamoto, M., Morita, Y., Itoh, T., Kuroda, Y., Hisatomi, H."Clinical implications of telomerase activity in resected hepatocellular carcinoma.". International Journal of Molecular Medicine 4.3 (1999): 267-338.
Chicago
Kanamaru, T., Yamamoto, M., Morita, Y., Itoh, T., Kuroda, Y., Hisatomi, H."Clinical implications of telomerase activity in resected hepatocellular carcinoma.". International Journal of Molecular Medicine 4, no. 3 (1999): 267-338. https://doi.org/10.3892/ijmm.4.3.267