A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review).

  • Authors:
    • M Kizaki
    • Y Fukuchi
    • Y Ikeda
  • View Affiliations

  • Published online on: October 1, 1999     https://doi.org/10.3892/ijmm.4.4.359
  • Pages: 359-423
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Abstract

Differentiation-inducing therapy by all-trans retinoic acid (RA) is now a standard therapy in patients with acute promyelocytic leukemia (APL). Nearly all patients achieve complete remission by the treatment of all-trans RA, however, clinical remissions are usually of brief duration, and these patients often develop RA-resistant disease. The mechanisms of RA-resistance in APL cells are poorly understood and most clinical approaches have not been successful in overcoming RA-resistance. We have recently established a novel APL cell line (UF-1) with RA-resistant features. In addition, we have established human GM-CSF-producing transgenic (hGMTg) SCID mice system. UF-1 cells were inoculated either intraperitoneally or subcutaneously into hGMTg SCID mice and made the first RA-resistant murine APL model. These RA-resistant APL model systems in vitro and in vivo may be useful for investigating the molecular studies on the block of leukemic cell differentiation and as means to investigate the mechanisms of RA-resistance. Moreover, this murine model system will be important for developing novel therapeutic strategies in RA-resistant APL.

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Oct 1999
Volume 4 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kizaki M, Fukuchi Y and Ikeda Y: A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review).. Int J Mol Med 4: 359-423, 1999
APA
Kizaki, M., Fukuchi, Y., & Ikeda, Y. (1999). A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review).. International Journal of Molecular Medicine, 4, 359-423. https://doi.org/10.3892/ijmm.4.4.359
MLA
Kizaki, M., Fukuchi, Y., Ikeda, Y."A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review).". International Journal of Molecular Medicine 4.4 (1999): 359-423.
Chicago
Kizaki, M., Fukuchi, Y., Ikeda, Y."A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review).". International Journal of Molecular Medicine 4, no. 4 (1999): 359-423. https://doi.org/10.3892/ijmm.4.4.359