Cortical motor potential alterations in chronic fatigue syndrome.

Gordon,R; Michalewski,H J; Nguyen,T; Gupta,S; Starr,A

doi:10.3892/ijmm.4.5.493

Nov 1999 Volume 4 Issue 5

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Nov 1999 Volume 4 Issue 5

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Article

Cortical motor potential alterations in chronic fatigue syndrome.

Authors:
- R Gordon
- H J Michalewski
- T Nguyen
- S Gupta
- A Starr
View Affiliations / Copyright

Affiliations: Department of Neurology, University of California, Irvine, Med. Surge I, Room 154, Irvine, CA 92697-4290, USA.
Pages: 493-502
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Published online on: November 1, 1999

https://doi.org/10.3892/ijmm.4.5.493
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Abstract

Premovement, sensory, and cognitive brain potentials were recorded from patients with Chronic Fatigue Syndrome (CFS) in four tasks: i) target detection, ii) short-term memory, iii) self-paced movement, and iv) expectancy and reaction time (CNV). Accuracy and reaction times (RTs) were recorded for tasks i, ii, and iv. Results from CFS patients were compared to a group of healthy normals. Reaction times were slower for CFS patients in target detection and significantly slower in the short-term memory task compared to normals. In target detection, the amplitude of a premovement readiness potential beginning several hundred milliseconds prior to stimulus onset was reduced in CFS, whereas the poststimulus sensory (N100) and cognitive brain potentials (P300) did not differ in amplitude or latency. In the memory task, a negative potential related to memory load was smaller in CFS than normals. The potentials to self-paced movements and to expectancy and RT (CNV) were not different between groups. The findings in CFS of slowed RTs and reduced premovement-related potentials suggest that central motor mechanisms accompanying motor response preparation were impaired in CFS for some tasks. In contrast, measures of neural processes related to both sensory encoding (N100) and to stimulus classification (P300) were normal in CFS.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cortical motor potential alterations in chronic fatigue syndrome.

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