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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Nov 1999 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov 1999 Volume 4 Issue 5

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Article

Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.

  • Authors:
    • Y Yamanishi
    • K Hiyama
    • S Ishioka
    • H Maeda
    • T Yamanaka
    • Y Kurose
    • M Yamakido

  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551, Japan.
  • Pages: 513-520
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/ijmm.4.5.513
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Abstract

Telomerase is a ribonucleoprotein complex which can compensate for telomeric loss originating from each cell division, and its activation plays a critical role in cellular immortality. We previously found that telomerase is activated not only in immortal cancer cells but also in activated lymphocytes. To assess the diagnostic significance of telomerase activity in RA synovial tissues, we quantitatively examined telomerase activity in synovial tissue samples obtained from 47 patients with RA, 31 with osteoarthritis (OA), and 23 with other joint diseases. Telomerase activity in synovial tissues was detected in 28 of 47 (59.6%) patients with RA, including monoarticular-type RA, but in none of those with other joint diseases except one case each of synovial chondromatosis and OA. Thus, the specificity of telomerase activity in synovial tissues for RA among joint diseases was 96.3% (52/54). In RA samples, the telomerase activity was detected in 14 of 27 (51. 9%) patients with total joint replacement, 7 of 12 (58.3%) open synovectomy cases, and 7 of 8 (87.5%) arthroscopic synovectomy cases. Detection of telomerase activity in synovial tissues is considered to be useful for diagnosis of RA, including monoarticular-type RA, or active inflammation with lymphocyte infiltration, and arthroscopy can be applied for this purpose.

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Copy and paste a formatted citation
Spandidos Publications style
Yamanishi Y, Hiyama K, Ishioka S, Maeda H, Yamanaka T, Kurose Y and Yamakido M: Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.. Int J Mol Med 4: 513-520, 1999.
APA
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., & Yamakido, M. (1999). Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.. International Journal of Molecular Medicine, 4, 513-520. https://doi.org/10.3892/ijmm.4.5.513
MLA
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., Yamakido, M."Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.". International Journal of Molecular Medicine 4.5 (1999): 513-520.
Chicago
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., Yamakido, M."Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.". International Journal of Molecular Medicine 4, no. 5 (1999): 513-520. https://doi.org/10.3892/ijmm.4.5.513
Copy and paste a formatted citation
x
Spandidos Publications style
Yamanishi Y, Hiyama K, Ishioka S, Maeda H, Yamanaka T, Kurose Y and Yamakido M: Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.. Int J Mol Med 4: 513-520, 1999.
APA
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., & Yamakido, M. (1999). Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.. International Journal of Molecular Medicine, 4, 513-520. https://doi.org/10.3892/ijmm.4.5.513
MLA
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., Yamakido, M."Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.". International Journal of Molecular Medicine 4.5 (1999): 513-520.
Chicago
Yamanishi, Y., Hiyama, K., Ishioka, S., Maeda, H., Yamanaka, T., Kurose, Y., Yamakido, M."Telomerase activity in the synovial tissues of chronic inflammatory and non-inflammatory rheumatic diseases.". International Journal of Molecular Medicine 4, no. 5 (1999): 513-520. https://doi.org/10.3892/ijmm.4.5.513
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