Angiogenesis in lipoma: An experimental study in the chick embryo chorioallantoic membrane.

Lucarelli,E; Sangiorgi,L; Benassi,S; Donati,D; Gobbi,G A; Picci,P; Vacca,A; Ribatti,D

doi:10.3892/ijmm.4.6.593

Dec 1999 Volume 4 Issue 6

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Dec 1999 Volume 4 Issue 6

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Article

Angiogenesis in lipoma: An experimental study in the chick embryo chorioallantoic membrane.

Authors:
- E Lucarelli
- L Sangiorgi
- S Benassi
- D Donati
- G A Gobbi
- P Picci
- A Vacca
- D Ribatti
View Affiliations / Copyright

Affiliations: Laboratory of Oncology Research, Rizzoli Orthopedic Institute, 40136 Bologna, Italy.
Pages: 593-599
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Published online on: December 1, 1999

https://doi.org/10.3892/ijmm.4.6.593
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Abstract

Lipoma is one of the most common benign mesenchymal tumors. Its ability to trigger an angiogenic response is a critical step for its growth. Because adipose tissue serves as an important conduit for the vasculature, it is conceivable that the angiogenic properties of this tissue may modulate the growth of the vasculature in a paracrine manner. We investigated in vivo the angiogenic potential of bioptic fragments of human lipoma by using the chick embryo chorioallantoic membrane (CAM), a useful model for such an investigation. The angiogenic response in pathological and control implants was assessed on histologic sections by a morphometric method, 96 h after grafting. Results showed that pathological samples were surrounded by numerous allantoic vessels with a radially arranged pattern around the implant. The vascular counts in the CAMs treated with lipoma implants were comparable to that of FGF-2. The role played in vasoproliferative response by angiogenic cytokines (FGF-2, VEGF) released by adipocytes, by endogenous cytokines, such as FGF-2, stored in the CAM extracellular matrix and by angiogenic growth factors released by perivascular mononuclear cells around the newly-formed blood vessels, were supported by this study.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Angiogenesis in lipoma: An experimental study in the chick embryo chorioallantoic membrane.

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