Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.

  • Authors:
    • L C Lim
    • K K Heng
    • M Vellupillai
    • L T Tan
    • B C Boey
    • L C Lau
    • G F How
  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijmm.4.6.665
  • Pages: 665-672
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Abstract

The Philadelphia chromosome is present in a heterogeneous group of leukemias. It is most commonly associated with chronic myelogenous leukemia (CML) and B-lineage acute lymphoblastic leukemia (ALL) being found in more than 95% and 15-25% of cases respectively. We undertook a study to determine the morphologic, phenotypic and molecular diversity of Philadelphia positive de novo acute leukemia patients seen at our institution over the past 3 1/2 years. Twenty-one patients with de novo acute leukemia were found to have the Philadelphia chromosome by cytogenetic studies. They consisted of 3 patients with acute myelogenous leukemia (AML), 1 biphenotypic leukemia and 17 ALL patients. Of the patients with ALL, 16 were of B-lineage while 1 had a T-cell phenotype. Ten patients expressed the p210 BCR-ABL transcript alone and 10 expressed only the p190 BCR-ABL transcript. One patient had co-expression of p190 and p210 b3a2 BCR-ABL transcripts. Thus the Philadelphia chromosome can be found in a diverse cohort of morphologic and immunologic subtypes of de novo acute leukemia reflecting the heterogeneity of lineage involvement in this disease.

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Dec 1999
Volume 4 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lim L, Heng K, Vellupillai M, Tan L, Boey B, Lau L and How G: Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. Int J Mol Med 4: 665-672, 1999.
APA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., & How, G. (1999). Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. International Journal of Molecular Medicine, 4, 665-672. https://doi.org/10.3892/ijmm.4.6.665
MLA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4.6 (1999): 665-672.
Chicago
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4, no. 6 (1999): 665-672. https://doi.org/10.3892/ijmm.4.6.665