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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Jan 2000 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 2000 Volume 5 Issue 1

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Article

Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.

  • Authors:
    • M Miyagishi
    • T Nakajima
    • A Fukamizu
  • View Affiliations / Copyright

    Affiliations: Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, University of Tsukuba, Japan.
  • Pages: 27-58
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijmm.5.1.27
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Abstract

Members of the basic helix-loop-helix (bHLH) family of transcription factors have been implicated in the regulation of cell proliferation and differentiation. Here we describe molecular characterization of mesoderm-specific bHLH protein, POD-1/Capsulin. Northern blot analysis showed that POD-1/Capsulin are preferentially expressed in human vascular smooth muscle cells, and are enriched in mouse heart, kidney, testis, spleen, and lung. Ectopic expression of the HA-tagged POD-1/Capsulin in 293T cells revealed that this protein has an apparent molecular mass of 26 kDa and localized in the nucleus. Furthermore, in order to identify possible interactants of the bHLH protein, we performed yeast two-hybrid screen in a human kidney cDNA library, and identified alternative-splicing form of HEB, as potential heterodimeric partner of POD-1/Capsulin. Our results provide the molecular basis for cell type-specific transcriptional regulation by POD-1/Capsulin.

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Copy and paste a formatted citation
Spandidos Publications style
Miyagishi M, Nakajima T and Fukamizu A: Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.. Int J Mol Med 5: 27-58, 2000.
APA
Miyagishi, M., Nakajima, T., & Fukamizu, A. (2000). Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.. International Journal of Molecular Medicine, 5, 27-58. https://doi.org/10.3892/ijmm.5.1.27
MLA
Miyagishi, M., Nakajima, T., Fukamizu, A."Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.". International Journal of Molecular Medicine 5.1 (2000): 27-58.
Chicago
Miyagishi, M., Nakajima, T., Fukamizu, A."Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.". International Journal of Molecular Medicine 5, no. 1 (2000): 27-58. https://doi.org/10.3892/ijmm.5.1.27
Copy and paste a formatted citation
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Spandidos Publications style
Miyagishi M, Nakajima T and Fukamizu A: Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.. Int J Mol Med 5: 27-58, 2000.
APA
Miyagishi, M., Nakajima, T., & Fukamizu, A. (2000). Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.. International Journal of Molecular Medicine, 5, 27-58. https://doi.org/10.3892/ijmm.5.1.27
MLA
Miyagishi, M., Nakajima, T., Fukamizu, A."Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.". International Journal of Molecular Medicine 5.1 (2000): 27-58.
Chicago
Miyagishi, M., Nakajima, T., Fukamizu, A."Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.". International Journal of Molecular Medicine 5, no. 1 (2000): 27-58. https://doi.org/10.3892/ijmm.5.1.27
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