Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.

  • Authors:
    • L Ladriere
    • F Bjorkling
    • W J Malaisse
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/ijmm.5.1.63
  • Pages: 63-68
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Abstract

Hereditarily diabetic Goto-Kakizaki rats were infused for 5 min with saline, containing as required nateglinide or mixed molecules (HD154 and HD166) with both a nateglinide moiety and a succinic acid ester moiety. The dose of these agents given intravenously amounted to 5.0 nmol/g body weight in all cases. All agents provoked a comparable early increase in plasma insulin concentration. However, HD154 and HD166, but not nateglinide itself, also caused a secondary rise in plasma insulin concentration 30 min after their infusion. It is proposed that mixed molecules formed of both a hypoglycemic sulfonylurea or meglitinide analog and a succinic acid ester may be better able than the antidiabetic agents themselves to evoke a sustained stimulation of insulin release in non-insulin-dependent diabetes.

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Jan 2000
Volume 5 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ladriere L, Bjorkling F and Malaisse W: Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.. Int J Mol Med 5: 63-68, 2000
APA
Ladriere, L., Bjorkling, F., & Malaisse, W. (2000). Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.. International Journal of Molecular Medicine, 5, 63-68. https://doi.org/10.3892/ijmm.5.1.63
MLA
Ladriere, L., Bjorkling, F., Malaisse, W."Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.". International Journal of Molecular Medicine 5.1 (2000): 63-68.
Chicago
Ladriere, L., Bjorkling, F., Malaisse, W."Stimulation of insulin release in hereditarily diabetic rats by mixed molecules formed of nateglinide and a succinic acid ester.". International Journal of Molecular Medicine 5, no. 1 (2000): 63-68. https://doi.org/10.3892/ijmm.5.1.63