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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Jan 2000 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan 2000 Volume 5 Issue 1

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Article

The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.

  • Authors:
    • F Garcia Soriano
    • A C Seguro
    • I Tadeu Velasco

  • View Affiliations / Copyright

    Affiliations: Departamento de Clinica Medica da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Pages: 71-77
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/ijmm.5.1.71
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Abstract

Endothelial cells have ectonucleotidases that catabolize extracellular nucleotides and are sensitive to the presence of cations. Our aim was to determine whether the metabolism of extracellular nucleotides is influenced by exposure of endothelial cells to high potassium relevant to human pathophysiology. Human umbilical vein endothelial cells were incubated with 25 mM potassium and without potassium. The metabolism of radioactive substrates was measured and activities were 7.0+/-1.3 and 12.2+/-1.4 microM P/h/mg of protein with and without potassium. Also incubation with membrane pellet from endothelial cells was used, this assay showed 15.5+/-1.9 and 20.9+/-0.7 microM P/ h/mg of protein with and without potassium, respectively. HPLC analysis of supernatant showed that AMP production was lower in the presence of 25 mM potassium. Analysis of different potassium levels showed that a progressive reduction occurred above 10 mM potassium. We conclude those potassium levels above 10 mM, which can be found in ischemia, inhibit the catabolism of extracellular adenine nucleotides by the ectonucleotidases of endothelial cells and may thus modify the pathophysiology of ischemia-reperfusion injury.

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Copy and paste a formatted citation
Spandidos Publications style
Garcia Soriano F, Seguro A and Tadeu Velasco I: The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.. Int J Mol Med 5: 71-77, 2000.
APA
Garcia Soriano, F., Seguro, A., & Tadeu Velasco, I. (2000). The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.. International Journal of Molecular Medicine, 5, 71-77. https://doi.org/10.3892/ijmm.5.1.71
MLA
Garcia Soriano, F., Seguro, A., Tadeu Velasco, I."The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.". International Journal of Molecular Medicine 5.1 (2000): 71-77.
Chicago
Garcia Soriano, F., Seguro, A., Tadeu Velasco, I."The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.". International Journal of Molecular Medicine 5, no. 1 (2000): 71-77. https://doi.org/10.3892/ijmm.5.1.71
Copy and paste a formatted citation
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Spandidos Publications style
Garcia Soriano F, Seguro A and Tadeu Velasco I: The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.. Int J Mol Med 5: 71-77, 2000.
APA
Garcia Soriano, F., Seguro, A., & Tadeu Velasco, I. (2000). The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.. International Journal of Molecular Medicine, 5, 71-77. https://doi.org/10.3892/ijmm.5.1.71
MLA
Garcia Soriano, F., Seguro, A., Tadeu Velasco, I."The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.". International Journal of Molecular Medicine 5.1 (2000): 71-77.
Chicago
Garcia Soriano, F., Seguro, A., Tadeu Velasco, I."The role of potassium in the regulation of adenosine production by ATP-diphosphohydrolase on the endothelial cell membrane.". International Journal of Molecular Medicine 5, no. 1 (2000): 71-77. https://doi.org/10.3892/ijmm.5.1.71
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