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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Feb 2000 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 2000 Volume 5 Issue 2

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Article

Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.

  • Authors:
    • G Su
    • G Casey
    • J K Cowell

  • View Affiliations / Copyright

    Affiliations: Center for Molecular Genetics/NB20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
  • Pages: 197-397
    |
    Published online on: February 1, 2000
       https://doi.org/10.3892/ijmm.5.2.197
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Abstract

Loss of heterozygosity (LOH) in 1p31 is a frequent genetic alteration in breast tumors indicating the site of a tumor suppressor gene. We recently isolated a new member of the human tetratricopeptide repeat-containing family of genes, TTC4, which maps to this region. Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. We now report the exon/intron structure of TTC4 and single strand conformation polymorphism (SSCP) analysis of DNA from 20 sporadic breast tumors. Although polymorphic variations were identified no mutations affecting the open reading frame of TTC4 were detected. Since the overall region of chromosome 1p31 which undergoes LOH can be relatively large, excluding involvement of newly isolated genes from this region in breast cancer tumorigenesis is an important process for the successful identification of the critical gene. Understanding the structure of TTC4 now makes mutation analysis possible for other cancers and diseases that map to this region.

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Copy and paste a formatted citation
Spandidos Publications style
Su G, Casey G and Cowell J: Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. Int J Mol Med 5: 197-397, 2000.
APA
Su, G., Casey, G., & Cowell, J. (2000). Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. International Journal of Molecular Medicine, 5, 197-397. https://doi.org/10.3892/ijmm.5.2.197
MLA
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5.2 (2000): 197-397.
Chicago
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5, no. 2 (2000): 197-397. https://doi.org/10.3892/ijmm.5.2.197
Copy and paste a formatted citation
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Spandidos Publications style
Su G, Casey G and Cowell J: Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. Int J Mol Med 5: 197-397, 2000.
APA
Su, G., Casey, G., & Cowell, J. (2000). Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. International Journal of Molecular Medicine, 5, 197-397. https://doi.org/10.3892/ijmm.5.2.197
MLA
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5.2 (2000): 197-397.
Chicago
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5, no. 2 (2000): 197-397. https://doi.org/10.3892/ijmm.5.2.197
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