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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Oct 2000 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.

  • Authors:
    • E Edström
    • T Frisk
    • F Farnebo
    • A Höög
    • M Bäckdahl
    • C Larsson

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Karolinska Hospital P9:03, SE-171 76 Stockholm, Sweden. Elisabeth.Edstrom@ks.se
  • Pages: 469-543
    |
    Published online on: October 1, 2000
       https://doi.org/10.3892/ijmm.6.4.469
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Abstract

Pheochromocytoma and its extra-adrenal counterpart paraganglioma are rare catecholamine producing tumors which usually occur sporadically but may also be a part of neuroendocrine tumor syndromes such as multiple endocrine neoplasia type 2A (MEN 2A). Activating mutations of the RET proto-oncogene which is the underlying cause of MEN 2A, is also seen in approximately 10% of sporadic pheochromocytomas. Glial cell line derived neurotrophic factor (GDNF) and neurturin (NTN) have been shown to function as independent ligands to RET, binding in a complex with the membrane-bound receptors GFRalpha-1 and GFRalpha-2 respectively. Here we have investigated the mRNA expression of RET and its ligand complexes, GDNF/GFRalpha-1 and NTN/GFRalpha-2, in a panel of pheochromocytomas and paragangliomas using mRNA in situ hybridization. RET expression was evident in normal adrenal medulla, and in 13/15 pheochromocytomas, including 5/5 MEN 2A associated tumors, but only in 1/10 paragangliomas. The frequent expression of RET in the pheochromocytomas suggest that this gene might be involved in the tumorigenesis. However, no expression of GDNF/GFRalpha-1 or NTN/GFRalpha-2 could be detected in any of the 25 tumors analyzed, suggesting that these ligand complexes are not important in the development of pheochromocytoma or paraganglioma.

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Copy and paste a formatted citation
Spandidos Publications style
Edström E, Frisk T, Farnebo F, Höög A, Bäckdahl M and Larsson C: Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.. Int J Mol Med 6: 469-543, 2000.
APA
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., & Larsson, C. (2000). Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.. International Journal of Molecular Medicine, 6, 469-543. https://doi.org/10.3892/ijmm.6.4.469
MLA
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., Larsson, C."Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.". International Journal of Molecular Medicine 6.4 (2000): 469-543.
Chicago
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., Larsson, C."Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.". International Journal of Molecular Medicine 6, no. 4 (2000): 469-543. https://doi.org/10.3892/ijmm.6.4.469
Copy and paste a formatted citation
x
Spandidos Publications style
Edström E, Frisk T, Farnebo F, Höög A, Bäckdahl M and Larsson C: Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.. Int J Mol Med 6: 469-543, 2000.
APA
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., & Larsson, C. (2000). Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.. International Journal of Molecular Medicine, 6, 469-543. https://doi.org/10.3892/ijmm.6.4.469
MLA
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., Larsson, C."Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.". International Journal of Molecular Medicine 6.4 (2000): 469-543.
Chicago
Edström, E., Frisk, T., Farnebo, F., Höög, A., Bäckdahl, M., Larsson, C."Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.". International Journal of Molecular Medicine 6, no. 4 (2000): 469-543. https://doi.org/10.3892/ijmm.6.4.469
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