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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Nov 2000 Volume 6 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov 2000 Volume 6 Issue 5

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Article

Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.

  • Authors:
    • Z A Darieva
    • E B Lasunskaia
    • T L Kipnis
    • W Dias Da Silva

  • View Affiliations / Copyright

    Affiliations: Laboratorio de Biologia do Reconhecer, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos/RJ, Rio de Janeiro, Brazil.
  • Pages: 575-655
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/ijmm.6.5.575
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Abstract

Two BCG vaccine formulations of the Moreau strain, commercially manufactured for anti-tuberculosis vaccination, ID-BCG, or anti-cancer adjuvant therapy, Onco-BCG, were compared for immunogenic activity in vitro. The growth rates of both vaccines in murine macrophages were the same, however, Onco-BCG induced stronger and longer-lasting secretion of TNF-alpha, IL-6 and nitric oxide. Onco-vaccine was also more potent in inducing NF-kappaB p65/p50 DNA-binding activity whilst in ID-BCG-infected cells the activity was transient and then gradually replaced by the transcriptionally inactive homodimer p50/p50. Comparative analysis of mycobacterial antigens of the two vaccines demonstrated a difference in expression of the 19 kDa and 38 kDa lipoproteins detected only in Onco-BCG extracts. These results suggest that these molecules may be responsible for the vigorous activation of macrophages induced by the Onco-vaccine. The data obtained show that vaccines from the same BCG strain, when manufactured differently, can vary significantly in their antigen expression and, consequently, in their capacity for macrophage activation which could contribute to the difference in their immunopotentiating effects.

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Copy and paste a formatted citation
Spandidos Publications style
Darieva Z, Lasunskaia E, Kipnis T and Dias Da Silva W: Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.. Int J Mol Med 6: 575-655, 2000.
APA
Darieva, Z., Lasunskaia, E., Kipnis, T., & Dias Da Silva, W. (2000). Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.. International Journal of Molecular Medicine, 6, 575-655. https://doi.org/10.3892/ijmm.6.5.575
MLA
Darieva, Z., Lasunskaia, E., Kipnis, T., Dias Da Silva, W."Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.". International Journal of Molecular Medicine 6.5 (2000): 575-655.
Chicago
Darieva, Z., Lasunskaia, E., Kipnis, T., Dias Da Silva, W."Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.". International Journal of Molecular Medicine 6, no. 5 (2000): 575-655. https://doi.org/10.3892/ijmm.6.5.575
Copy and paste a formatted citation
x
Spandidos Publications style
Darieva Z, Lasunskaia E, Kipnis T and Dias Da Silva W: Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.. Int J Mol Med 6: 575-655, 2000.
APA
Darieva, Z., Lasunskaia, E., Kipnis, T., & Dias Da Silva, W. (2000). Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.. International Journal of Molecular Medicine, 6, 575-655. https://doi.org/10.3892/ijmm.6.5.575
MLA
Darieva, Z., Lasunskaia, E., Kipnis, T., Dias Da Silva, W."Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.". International Journal of Molecular Medicine 6.5 (2000): 575-655.
Chicago
Darieva, Z., Lasunskaia, E., Kipnis, T., Dias Da Silva, W."Two BCG vaccine formulations prepared from the same strain with different J774 macrophage activation capacities and patterns of NF-kappaB induction.". International Journal of Molecular Medicine 6, no. 5 (2000): 575-655. https://doi.org/10.3892/ijmm.6.5.575
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