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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Dec 2000 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 2000 Volume 6 Issue 6

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Article

Elevated serum soluble CD44 level in sarcoidosis.

  • Authors:
    • I Kasuga
    • K Minemura
    • H Nasu
    • N Hibi
    • H Tago
    • A Nagate
    • A Kunisawa
    • J H Ohyashiki
    • K Ohyashiki

  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan.
  • Pages: 679-761
    |
    Published online on: December 1, 2000
       https://doi.org/10.3892/ijmm.6.6.679
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Abstract

Sarcoidosis is a chronic multi-organ granulomatous disease of unknown etiology. Several studies have suggested an involvement of immunologic background in sarcoidosis. The lymphocyte surface marker CD44 is a multifunctional molecule which mediates the adhesion of lymphocytes to the extracellular matrix. Recently, we developed a system to quantitate soluble CD44 (sCD44) which we employed to determine serum and bronchoalveolar lavage fluid (BALF) levels of sCD44 to obtain further insights into immunologic aspects of sarcoidosis. Serum sCD44 levels were measured in 13 consecutive patients with sarcoidosis and 56 normal healthy controls using enzyme-linked immunoabsorbent assay. BALF sCD44 levels were also measured in 11 patients with sarcoidosis and 10 normal healthy controls. In patients with sarcoidosis, the serum sCD44 level was significantly higher than that of normal controls (348.5+/-164.2 ng/ml vs 145.4+/-22.9 ng/ml; p<0.001). Also BALF sCD44 levels tended to be higher in sarcoidosis than in normal controls (23.7+/-13.4 ng/ml vs 18.1+/-8.4 ng/ml), but no statistically significant difference was recognized. We also found that there was a positive correlation between the serum sCD44 and angiotensin converting enzyme (r=0.78). Our data indicate that sCD44 may be related to immunologic background and may be a useful new marker of sarcoidosis.

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Copy and paste a formatted citation
Spandidos Publications style
Kasuga I, Minemura K, Nasu H, Hibi N, Tago H, Nagate A, Kunisawa A, Ohyashiki J and Ohyashiki K: Elevated serum soluble CD44 level in sarcoidosis.. Int J Mol Med 6: 679-761, 2000.
APA
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A. ... Ohyashiki, K. (2000). Elevated serum soluble CD44 level in sarcoidosis.. International Journal of Molecular Medicine, 6, 679-761. https://doi.org/10.3892/ijmm.6.6.679
MLA
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A., Kunisawa, A., Ohyashiki, J., Ohyashiki, K."Elevated serum soluble CD44 level in sarcoidosis.". International Journal of Molecular Medicine 6.6 (2000): 679-761.
Chicago
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A., Kunisawa, A., Ohyashiki, J., Ohyashiki, K."Elevated serum soluble CD44 level in sarcoidosis.". International Journal of Molecular Medicine 6, no. 6 (2000): 679-761. https://doi.org/10.3892/ijmm.6.6.679
Copy and paste a formatted citation
x
Spandidos Publications style
Kasuga I, Minemura K, Nasu H, Hibi N, Tago H, Nagate A, Kunisawa A, Ohyashiki J and Ohyashiki K: Elevated serum soluble CD44 level in sarcoidosis.. Int J Mol Med 6: 679-761, 2000.
APA
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A. ... Ohyashiki, K. (2000). Elevated serum soluble CD44 level in sarcoidosis.. International Journal of Molecular Medicine, 6, 679-761. https://doi.org/10.3892/ijmm.6.6.679
MLA
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A., Kunisawa, A., Ohyashiki, J., Ohyashiki, K."Elevated serum soluble CD44 level in sarcoidosis.". International Journal of Molecular Medicine 6.6 (2000): 679-761.
Chicago
Kasuga, I., Minemura, K., Nasu, H., Hibi, N., Tago, H., Nagate, A., Kunisawa, A., Ohyashiki, J., Ohyashiki, K."Elevated serum soluble CD44 level in sarcoidosis.". International Journal of Molecular Medicine 6, no. 6 (2000): 679-761. https://doi.org/10.3892/ijmm.6.6.679
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