A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma.

  • Authors:
    • F L Imai
    • K Uzawa
    • A Miyakawa
    • M Shiiba
    • H Tanzawa
  • View Affiliations

  • Published online on: January 1, 2001     https://doi.org/10.3892/ijmm.7.1.43
  • Pages:43-50
0

Abstract

Loss of heterozygosity (LOH) on the long arm of chromosome 20 (20q) has been detected in several human cancers. However, little is known about LOH on chromosome 20 in oral squamous cell carcinoma (OSCC). To determine which loci of chromosome 20 were involved in OSCC tumorigenesis, 41 cases of OSCC were examined for LOH state on chromosome 20 at 17 microsatellite loci by PCR-LOH assay. LOH occurred in 41.5% of tumors in at least one locus. Among the 17 loci, D20S48 on 20p11.2 and RPN2 on 20q12-13.1 exhibited higher frequencies of LOH, 27.6% and 31.4%, respectively. The LOH incidence was significantly higher in tumors in which the primary site was on gingiva compared with other oral sites (p=0.012). Our results indicate that allelic deletions on 20q12-13.1 and 20p11.2 may play roles in OSCC carcinogenesis, and suggest that allelic deletions on 20q might have some relation with the primary site of OSCC.

Related Articles

Journal Cover

January 2001
Volume 7 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Imai, F., Uzawa, K., Miyakawa, A., Shiiba, M., & Tanzawa, H. (2001). A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma.. International Journal of Molecular Medicine, 7, 43-50. https://doi.org/10.3892/ijmm.7.1.43
MLA
Imai, F., Uzawa, K., Miyakawa, A., Shiiba, M., Tanzawa, H."A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma.". International Journal of Molecular Medicine 7.1 (2001): 43-50.
Chicago
Imai, F., Uzawa, K., Miyakawa, A., Shiiba, M., Tanzawa, H."A detailed deletion map of chromosome 20 in human oral squamous cell carcinoma.". International Journal of Molecular Medicine 7, no. 1 (2001): 43-50. https://doi.org/10.3892/ijmm.7.1.43