Impaired Ca2+-sequestration in dilated cardiomyopathy (Review)

  • Authors:
    • N. J. Lennon
    • K. Ohlendieck
  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijmm.7.2.131
  • Pages: 131-141
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Abstract

Excitation-contraction coupling is the process by which depolarisation of the myocardial surface membrane leads to the release of Ca2+-ions from the sarcoplasmic reticulum, inducing cardiac muscle contraction. This process is made possible by an elaborate system of ion-release, uptake and sequestration that controls the contraction and relaxation cycle of heart muscle fibres. The free intracellular Ca2+-concentration determines the contractile state of the myocardium, and the sequestration of Ca2+-ions into the lumen of the sarcoplasmic reticulum by the Ca2+-ATPase pump units represents a critical step towards the maintenance of normal Ca2+-cycling. The Ca2+-ATPase pump activity is regulated by phospholamban, a small 52-amino acid protein whose phosphorylation state dictates its inhibitory action on the pump. A large body of evidence points to the central role of abnormal Ca2+-ATPase-phospholamban interactions in pathophysiological heart conditions, thereby compromising the contractile state of the cardiac muscle cell. It has been shown that alterations in the oligomeric status of the Ca2+-ATPase and modified interactions between the Ca2+-pump and its regulatory subunit phospholamban underlie the contractile dysfunction that characterises certain forms of dilated cardiomyopathy. Hence, elucidation of interactions within physiological Ca2+-ATPase pump units in normal and diseased myocardium is a vital link in the development of improved diagnostic and therapeutic techniques for dealing with this elusive condition.

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February 2001
Volume 7 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lennon NJ and Lennon NJ: Impaired Ca2+-sequestration in dilated cardiomyopathy (Review). Int J Mol Med 7: 131-141, 2001
APA
Lennon, N.J., & Lennon, N.J. (2001). Impaired Ca2+-sequestration in dilated cardiomyopathy (Review). International Journal of Molecular Medicine, 7, 131-141. https://doi.org/10.3892/ijmm.7.2.131
MLA
Lennon, N. J., Ohlendieck, K."Impaired Ca2+-sequestration in dilated cardiomyopathy (Review)". International Journal of Molecular Medicine 7.2 (2001): 131-141.
Chicago
Lennon, N. J., Ohlendieck, K."Impaired Ca2+-sequestration in dilated cardiomyopathy (Review)". International Journal of Molecular Medicine 7, no. 2 (2001): 131-141. https://doi.org/10.3892/ijmm.7.2.131